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Special Issue "Xenobiotics and Redox Regulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 192

Special Issue Editor

Prof. Dr. Demetrios Kouretas
E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, 41500 Larissa, Greece
Interests: antioxidant; oleuropein; elenolic acid

Special Issue Information

Dear Colleagues,

In this Special Issue, we invite authors to contribute their original manuscripts that describe the role of xenobiotics, including environmental pollutants, drugs, and dietary components, in cell metabolism regulation.

Xenobiotics can interfere with redox regulation by increasing ROS and RNS production or inhibiting antioxidant defense systems. This can lead to oxidative stress, which can damage cellular components such as proteins, lipids, and DNA. Oxidative stress has been implicated in a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative disorders, leading to a disruption in redox homeostasis, which refers to an imbalance between the production of ROS and RNS in the body.

On the other hand, some xenobiotics have been found to have beneficial effects on redox regulation. For example, certain plant-derived compounds, such as flavonoids and polyphenols, have been shown to possess antioxidant properties and can scavenge ROS and RNS or even increase the expression of critical antioxidant genes.

Overall, this Special Issue aims to describe the complex relationship between xenobiotics and redox regulation, which depends on the specific chemical compound and its concentration, as well as the individual's overall health and exposure history.

This Special Issue is supervised by Prof. Demetrios Kouretas and assisted by Dr. Fotios Tekos (University of Thessaly) and Dr. Zoi Skaperda (University of Thessaly).

Prof. Dr. Demetrios Kouretas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • xenobiotics
  • oxidative stress
  • free radicals
  • reactive oxygen species
  • reactive nitrogen species
  • antioxidants
  • glutathione
  • toxicology
  • redox metabolism
  • redox imbalance

Published Papers

This special issue is now open for submission.
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