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Modes of Action of Polyamine Metabolism 2.0
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Modes of Action of Polyamine Metabolism 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2314

Special Issue Editor

Dr. Ágnes Szepesi

E-Mail Website
Guest Editor
Department of Plant Biology, University of Szeged, H-6726 Szeged, Hungary
Interests: polyamines; salt stress; reactive oxygen species; hypusination; antioxidant defence system
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polyamines are N-containing essential compounds in all living organisms. Their metabolism is highly connected to other significant signal pathways, hormones and metabolites, making them hub molecules. Despite an enormous effort to study polyamine-mediated signal pathways and metabolic interactions, there is a lack of knowledge about the precise molecular modes of action of polyamine biosynthesis, degradation and transport mechanisms. New emerging evidence about the significance of polyamines is not only in development but also stress-induced responses support the aim of this Special Issue to deepen our knowledge of PA-related interactions. It is an urgent need to decipher these mechanisms not only in single organisms but also in more complex interactions between, for example, plants and microbes, or between microbes and the human body. This Special Issue invites contributors to publish their important work to describe new modes of action, polyamines-related metabolic modifications or molecular responses supporting the role of polyamines as growth regulators and hub molecules.

Dr Ágnes Szepesi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyamines
  • metabolites
  • modes of action
  • interactions
  • polyamine transport
  • polyamine biosynthesis
  • polyamine catabolism

Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 1168 KiB  
Article
Dynamics of Polyamines, Proline, and Ethylene Metabolism under Increasing Cold in Winter Oilseed Rape
by Elžbieta Jankovska-Bortkevič, Sigita Jurkonienė, Virgilija Gavelienė, Vaidevutis Šveikauskas, Rima Mockevičiūtė, Irina Vaseva, Dessislava Todorova, Marija Žižytė-Eidetienė, Donatas Šneideris and Petras Prakas
Int. J. Mol. Sci. 2023, 24(14), 11402; https://doi.org/10.3390/ijms241411402 - 13 Jul 2023
Cited by 1 | Viewed by 861
Abstract
Cold stress is among the most important environmental factors reducing the yield of crops. The present study aimed to investigate the impact of increasing cold stress conditions on winter oilseed rape polyamines, proline, and ethylene metabolism in acclimated and non-acclimated winter oilseed rape. [...] Read more.
Cold stress is among the most important environmental factors reducing the yield of crops. The present study aimed to investigate the impact of increasing cold stress conditions on winter oilseed rape polyamines, proline, and ethylene metabolism in acclimated and non-acclimated winter oilseed rape. This study was carried out under controlled conditions in the laboratory. The winter oilseed rape hybrid ‘Visby’ was used in the experiment. Acclimated and non-acclimated plants were subjected to a two-day-long increasing cold (from −1 °C to −3 °C) treatment. HPTLC, RT-qPCR, spectral analysis, and gas chromatography methods were used to analyse the levels of polyamines, gene expression, proline, and ethylene, respectively. This study showed a decrease in putrescine, spermidine, and spermine content during cold acclimation and a decrease in putrescine and spermidine levels at sub-zero temperatures. There were intensive changes in ADC2 gene expression, proline, and ethylene levels in non-acclimated plants: a substantial increase after exposure to −1 °C temperature and a sharp decrease after exposure to −3 °C temperature. The changes in these parameters were lower or absent in acclimated plants. The phenomena observed in this study add new insights to the knowledge about the plant stress response and suggest questions to be answered in the future. Full article
(This article belongs to the Special Issue Modes of Action of Polyamine Metabolism 2.0)
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14 pages, 2151 KiB  
Article
Carrier-Mediated Process of Putrescine Elimination at the Rat Blood–Retinal Barrier
by Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri, Ayaka Tomise, Shin-ichi Akanuma and Ken-ichi Hosoya
Int. J. Mol. Sci. 2023, 24(10), 9003; https://doi.org/10.3390/ijms24109003 - 19 May 2023
Viewed by 988
Abstract
Putrescine is a bioactive polyamine. Its retinal concentration is strictly controlled to maintain a healthy sense of vision. The present study investigated putrescine transport at the blood–retinal barrier (BRB) to gain a better understanding of the mechanisms of putrescine regulation in the retina. [...] Read more.
Putrescine is a bioactive polyamine. Its retinal concentration is strictly controlled to maintain a healthy sense of vision. The present study investigated putrescine transport at the blood–retinal barrier (BRB) to gain a better understanding of the mechanisms of putrescine regulation in the retina. Our microdialysis study showed that the elimination rate constant during the terminal phase was significantly greater (1.90-fold) than that of [14C]D-mannitol, which is a bulk flow marker. The difference in the apparent elimination rate constants of [3H]putrescine and [14C]D-mannitol was significantly decreased by unlabeled putrescine and spermine, suggesting active putrescine transport from the retina to the blood across the BRB. Our study using model cell lines of the inner and outer BRB showed that [3H]putrescine transport was time-, temperature-, and concentration-dependent, suggesting the involvement of carrier-mediated processes in putrescine transport at the inner and outer BRB. [3H]Putrescine transport was significantly reduced under Na+-free, Cl−-free, and K+-replacement conditions, and attenuated by polyamines or organic cations such as choline, a choline transporter-like protein (CTL) substrate. Rat CTL1 cRNA-injected oocytes exhibited marked alterations in [3H]putrescine uptake, and CTL1 knockdown significantly reduced [3H]putrescine uptake in model cell lines, suggesting the possible participation of CTL1 in putrescine transport at the BRB. Full article
(This article belongs to the Special Issue Modes of Action of Polyamine Metabolism 2.0)
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