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Special Issue "Magnetic Nanoparticles for Biomedical and Imaging Applications 2.0"

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Dear Colleagues,

Magnetic nanoparticles (MNPs) are spherical particles comprising various metals and their alloys (Fe, Ni, Co, etc.). They have diameters of 1–100 nm in size, a large surface area, colloidal stability, and unique optical properties. MNPs also possess great potential for use in targeted drug delivery, bioimaging, and cancer therapy. Due to the possibility of MNP functionalization with various ligands, they can be used for the magnetic separation of cells or biomolecules. Magnetic iron oxide nanoparticles are popular in biomedicine due to their high biocompatibility, ease of preparation, and optimal magnetic properties. Their small size, colloidal stability, and biological inertness allow them to be used as contrast agents for non-invasive imaging. In addition, the action of an external field on magnetic nanoparticles causes oscillations that flow into thermal energy; this is used for the induction of local hyperthermia, inhibiting the proliferation of cancer cells. In addition, by using magnetic nanoparticles, it is possible to obtain cellular substrates with a finely tuned architecture of surface nanotopography, allowing the effect of mechanical signals on cell growth and proliferation to be assessed.

Potential topics include, but are not limited to, the following:

Magnetic nanoparticles and targeted drug delivery;
Magnetic nanoparticles as instruments for nanotopography;
Magnetic nanoparticles for bioimaging;
Magnetic nanoparticles for cell and biomolecule separation;
Magnetic nanoparticles and non-invasive imaging;
Magnetic nanoparticles and nanocomposites.

Dr. Elvira Rozhina
Dr. Svetlana A. Konnova
Guest Editors

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Keywords

magnetic nanoparticles and targeted drug delivery
magnetic nanoparticles as instruments for nanotopography
magnetic nanoparticles for bioimaging
magnetic nanoparticles for cell and biomolecule separation
magnetic nanoparticles and non-invasive imaging
magnetic nanoparticles and nanocomposites

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17 pages, 2950 KiB

Open AccessArticle

Simplified Synthesis of the Amine-Functionalized Magnesium Ferrite Magnetic Nanoparticles and Their Application in DNA Purification Method

and

Int. J. Mol. Sci. 2023, 24(18), 14190; https://doi.org/10.3390/ijms241814190 - 16 Sep 2023

Viewed by 623

Abstract

For pathogens identification, the PCR test is a widely used method, which requires the isolation of nucleic acids from different samples. This extraction can be based on the principle of magnetic separation. In our work, amine-functionalized magnesium ferrite nanoparticles were synthesized for this application by the coprecipitation of ethanolamine in ethylene glycol from Mg(II) and Fe(II) precursors. The conventional synthesis method involves a reaction time of 12 h (MgFe₂O₄-H&R MNP); however, in our modified method, the reaction time could be significantly reduced to only 4 min by microwave-assisted synthesis (MgFe₂O₄-MW MNP). A comparison was made between the amine-functionalized MgFe₂O₄ samples prepared by two methods in terms of the DNA-binding capacity. The experimental results showed that the two types of amine-functionalized magnesium ferrite magnetic nanoparticles (MNPs) were equally effective in terms of their DNA extraction yield. Moreover, by using a few minutes-long microwave synthesis, we obtained the same quality magnesium ferrite particles as those made through the long and energy-intensive 12-h production method. This advancement has the potential to improve and expedite pathogen identification processes, helping to better prevent the spread of epidemics. Full article

(This article belongs to the Special Issue Magnetic Nanoparticles for Biomedical and Imaging Applications 2.0)

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Special Issue "Magnetic Nanoparticles for Biomedical and Imaging Applications 2.0"

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