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Non-small Cell Lung Cancer: Novel Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2034

Special Issue Editor


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Guest Editor
Oncoimmunology Group, Navarrabiomed, Fundación Miguel Servet-Hospital Universitario de Navarra-UPNA-IdISNA, Irunlarrea 3, 31008 Pamplona, Spain
Interests: lung cancer; respiratory diseases

Special Issue Information

Dear Colleagues,

Lung cancer is a major public health problem worldwide, being the leading cause of cancer death due to the long-term ineffectiveness of current therapies and the typically late stage at time of diagnosis. Specifically, the predominant lung cancer subtype, non-small cell lung cancer (NSCLC), accounts for 85% of lung-cancer-associated deaths. Thus, both novel biomarkers and therapeutic approaches for NSCLC are urgently needed.

Potential topics of relevance to this Special Issue include the following:

  • novel biomarkers for lung adenocarcinoma (LUAD),
  • novel biomarkers for lung squamous cell carcinoma (LUSC),
  • experimental therapeutics in NSCLC,
  • animal models of NSCLC,
  • in vitro models of NSCLC,
  • clinical trials in NSCLC.

Dr. Sergio Piñeiro Hermida
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • lung cancer
  • experimental therapeutics
  • novel therapeutic approaches

Published Papers (1 paper)

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Research

16 pages, 6189 KiB  
Article
Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells
by Alejandra Hernandez Pichardo, Francesco Amadeo, Bettina Wilm, Raphaël Lévy, Lorenzo Ressel, Patricia Murray and Violaine Sée
Int. J. Mol. Sci. 2022, 23(22), 14171; https://doi.org/10.3390/ijms232214171 - 16 Nov 2022
Cited by 4 | Viewed by 1753
Abstract
Mesenchymal stromal cells (MSCs) injected intravenously are trapped in the capillaries of the lungs and die within the first 24 h. Studying the biodistribution and fate of labelled therapeutic cells in the 3D pulmonary context is important to understand their function in this [...] Read more.
Mesenchymal stromal cells (MSCs) injected intravenously are trapped in the capillaries of the lungs and die within the first 24 h. Studying the biodistribution and fate of labelled therapeutic cells in the 3D pulmonary context is important to understand their function in this organ and gain insights into their mechanisms of action. Optical tissue clearing enables volumetric cell tracking at single-cell resolution. Thus, we compared three optical tissue-clearing protocols (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis (CUBIC), modified stabilised 3D imaging of solvent-cleared organs (s-DISCO) and ethyl cinnamate (ECi)) to evaluate their potential to track the biodistribution of human umbilical cord MSCs expressing the tdTomato fluorescence reporter and investigate how they interact with host cells in the mouse lung. The results showed that although CUBIC clearing is the only method that enables direct imaging of fluorescently labelled MSCs, combining s-DISCO or ECi with immunofluorescence or dye labelling allows the interaction of MSCs with endothelial and immune cells to be studied. Overall, this comparative study offers guidance on selecting an optical tissue-clearing method for cell tracking applications. Full article
(This article belongs to the Special Issue Non-small Cell Lung Cancer: Novel Therapeutic Approaches)
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