Special Issue "Glycomics and Glycosylation Disorders"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 January 2024 | Viewed by 1039
Special Issue Editor
Interests: protein stability; bioinformatics; PMM2-CDG; Fabry disease; pharmacological chaperones
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glycomics "is the systematic study of all glycan structures of a given cell type or organism". Compared with genomics, proteomics, and metabolomics, it is a relatively new field.
The glycome represents the whole content of glycans and glycoconjugates of an organism/cell type. Each kind of organism/cell type has its own glycome whose composition changes greatly from one to another. Vertebrates, for instance, have free glycans, lipid associated glycans, glycoproteins, glycosaminoglycans, and GPI anchors.
Glycans, either free or as a part of a more complex biomolecule, participate in almost every biological process. The synthesis, the transfer, and the modification of glycan moieties on biomolecules are a finely tuned process that requires many steps and involves hundreds of different enzymes/proteins.
The glycome is the result of genetic and environmental factors such as cellular nutrients and pH, but also age, gender, and other variables (for example, smoking). In short, the glycome is a highly diverse and dynamic system, and as a consequence, the information it contains could provide precious insight into the cellular functions underlying physiological, non-physiological, or pathological conditions.
It is well known that structural and conformational aspects of glycans are very complex, and even a small change in a glycan structure can strongly influence the chemophysical properties of the glycomolecule, but more importantly, it affects the biological function(s), and in these cases, glycosylation disorders might occur.
This Special Issue aims to collect any kind of papers (reviews, original papers, perspective papers) regarding structural and/or functional studies on glycans and glycoconjugates, as well as on those aspects that can shed light on their physiological roles, their biosynthesis, and on the physiopathology of disorders of glycosylation. Lastly, since the study of the glycomolecules is incredibly challenging, methodological approaches and innovative tools are topics of utmost importance to focus on as well.
Prof. Dr. Maria Vittoria Cubellis
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- glycome
- glycomics
- glycomic analysis
- glycans
- glycoproteins
- glycosylation pathway
- N-glycosylation
- O-glycosylation
- GPI anchor
- disorder of glycosylation
