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Special Issue "Glycomics and Glycosylation Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 1039

Special Issue Editor

Special Issue Information

Dear Colleagues,

Glycomics "is the systematic study of all glycan structures of a given cell type or organism". Compared with genomics, proteomics, and metabolomics, it is a relatively new field.

The glycome represents the whole content of glycans and glycoconjugates of an organism/cell type. Each kind of organism/cell type has its own glycome whose composition changes greatly from one to another. Vertebrates, for instance, have free glycans, lipid associated glycans, glycoproteins, glycosaminoglycans, and GPI anchors.

Glycans, either free or as a part of a more complex biomolecule, participate in almost every biological process. The synthesis, the transfer, and the modification of glycan moieties on biomolecules are a finely tuned process that requires many steps and involves hundreds of different enzymes/proteins.

The glycome is the result of genetic and environmental factors such as cellular nutrients and pH, but also age, gender, and other variables (for example, smoking). In short, the glycome is a highly diverse and dynamic system, and as a consequence, the information it contains could provide precious insight into the cellular functions underlying physiological, non-physiological, or pathological conditions.

It is well known that structural and conformational aspects of glycans are very complex, and even a small change in a glycan structure can strongly influence the chemophysical properties of the glycomolecule, but more importantly, it affects the biological function(s), and in these cases, glycosylation disorders might occur.

This Special Issue aims to collect any kind of papers (reviews, original papers, perspective papers) regarding structural and/or functional studies on glycans and glycoconjugates, as well as on those aspects that can shed light on their physiological roles, their biosynthesis, and on the physiopathology of disorders of glycosylation. Lastly, since the study of the glycomolecules is incredibly challenging, methodological approaches and innovative tools are topics of utmost importance to focus on as well.

Prof. Dr. Maria Vittoria Cubellis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • glycome
  • glycomics
  • glycomic analysis
  • glycans
  • glycoproteins
  • glycosylation pathway
  • N-glycosylation
  • O-glycosylation
  • GPI anchor
  • disorder of glycosylation

Published Papers (1 paper)

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The Alterations of Serum N-glycome in Response to SARS-CoV-2 Vaccination
Int. J. Mol. Sci. 2023, 24(7), 6203; https://doi.org/10.3390/ijms24076203 - 25 Mar 2023
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global concern since its outbreak in 2019, with one of the main solutions being vaccination. Altered glycosylation has been described in patients after SARS-CoV-2 infection, while the effect of vaccination on [...] Read more.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global concern since its outbreak in 2019, with one of the main solutions being vaccination. Altered glycosylation has been described in patients after SARS-CoV-2 infection, while the effect of vaccination on serum glycoproteins remained unexplored. In this study, total serum glycosylation was analyzed in patients after SARS-CoV-2 infection and/or mRNA vaccination in order to identify potential glycosylation-based alterations. Enzyme-linked immunosorbent assay was applied to identify post-COVID-19 and post-Vaccinated patients and rule out potential outliers. Serum samples were deglycosylated by PNGase F digestion, and the released glycans were fluorescently derivatized using procainamide labeling. Solid-phase extraction was used to purify the labeled glycans followed by the analysis of hydrophilic-interaction liquid chromatography with fluorescence and mass-spectrometric detection. Alterations of serum N-glycome in response to SARS-CoV-2 infection and mRNA vaccination were revealed by linear discriminant analysis. Full article
(This article belongs to the Special Issue Glycomics and Glycosylation Disorders)
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