Special Issue "Glycomics and Glycosylation Disorders"
Deadline for manuscript submissions: 31 January 2024 | Viewed by 1039
Interests: protein stability; bioinformatics; PMM2-CDG; Fabry disease; pharmacological chaperones
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Glycomics "is the systematic study of all glycan structures of a given cell type or organism". Compared with genomics, proteomics, and metabolomics, it is a relatively new field.
The glycome represents the whole content of glycans and glycoconjugates of an organism/cell type. Each kind of organism/cell type has its own glycome whose composition changes greatly from one to another. Vertebrates, for instance, have free glycans, lipid associated glycans, glycoproteins, glycosaminoglycans, and GPI anchors.
Glycans, either free or as a part of a more complex biomolecule, participate in almost every biological process. The synthesis, the transfer, and the modification of glycan moieties on biomolecules are a finely tuned process that requires many steps and involves hundreds of different enzymes/proteins.
The glycome is the result of genetic and environmental factors such as cellular nutrients and pH, but also age, gender, and other variables (for example, smoking). In short, the glycome is a highly diverse and dynamic system, and as a consequence, the information it contains could provide precious insight into the cellular functions underlying physiological, non-physiological, or pathological conditions.
It is well known that structural and conformational aspects of glycans are very complex, and even a small change in a glycan structure can strongly influence the chemophysical properties of the glycomolecule, but more importantly, it affects the biological function(s), and in these cases, glycosylation disorders might occur.
This Special Issue aims to collect any kind of papers (reviews, original papers, perspective papers) regarding structural and/or functional studies on glycans and glycoconjugates, as well as on those aspects that can shed light on their physiological roles, their biosynthesis, and on the physiopathology of disorders of glycosylation. Lastly, since the study of the glycomolecules is incredibly challenging, methodological approaches and innovative tools are topics of utmost importance to focus on as well.
Prof. Dr. Maria Vittoria Cubellis
Manuscript Submission Information
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- glycomic analysis
- glycosylation pathway
- GPI anchor
- disorder of glycosylation