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Tissue Engineering of the Heart and Blood Vessels
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Tissue Engineering of the Heart and Blood Vessels

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 10857

Special Issue Editor

Dr. Larisa Valeryevna Antonova

E-Mail Website
Guest Editor
Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovy Boulevard, Kemerovo 650002, Russia
Interests: vascular tissue engineering; polymeric heart valves; tissue-engineered vascular grafts; antithrombotic and antibacterial coating; vascular regeneration

Special Issue Information

Dear Colleagues,

The rapid development of tissue engineering makes it necessary to popularize scientific achievements that could provide a breakthrough in regenerative medicine. Considering that cardiovascular diseases are still the leading cause of death in the world population, vascular tissue engineering can provide many interesting solutions for the surgical and therapeutic treatment of this pathology. It is also relevant to study the fundamental aspects of the development of cardiovascular pathology, affecting intercellular interactions and the influence of various therapeutic agents that stimulate the regeneration of cardiac and vascular tissue. It is very important for the needs of cardiovascular surgery to create personalized biocompatible biomimetic scaffolds from modern synthetic and biodegradable polymers with the desired physical, mechanical, structural, and hemocompatible properties.

In this Special Issue entitled “Tissue Engineering of the Heart and Blood Vessels”, the focus will be on the development of tissue engineering structures for the restoration and remodeling of individual structures of the cardiovascular system, e.g., heart and vascular valve prostheses, to study the effectiveness of various biologically active components and biomedical cellular products that can affect the repair of cardiac and vascular tissue.

Regenerative medicine is directly related to the need for a personalized approach when creating tissue engineering structures. Therefore, authors with positive experience in the development of tissue engineering constructs based on cells or proteins of patients with cardiovascular diseases are also invited to publish in this Special Issue.

Experimental articles, review articles reflecting historical retrospectives and the current state of the problem, as well as comments are welcome.

Dr. Larisa Valeryevna Antonova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascular tissue engineering

  • biomaterials
  • biodegradable polymer
  • polymeric heart valves
  • tissue-engineered vascular grafts
  • antithrombotic and antibacterial coating
  • primary patency
  • nanocomposites
  • durability
  • immune response
  • hemocompatibility
  • vascular regeneration
  • chronic inflammation

Published Papers (3 papers)

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Research

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23 pages, 62125 KiB  
Article
Comparison of the Patency and Regenerative Potential of Biodegradable Vascular Prostheses of Different Polymer Compositions in an Ovine Model
by Larisa V. Antonova, Viktoriia V. Sevostianova, Vladimir N. Silnikov, Evgeniya O. Krivkina, Elena A. Velikanova, Andrey V. Mironov, Amin R. Shabaev, Evgenia A. Senokosova, Mariam Yu. Khanova, Tatiana V. Glushkova, Tatiana N. Akentieva, Anna V. Sinitskaya, Victoria E. Markova, Daria K. Shishkova, Arseniy A. Lobov, Egor A. Repkin, Alexander D. Stepanov, Anton G. Kutikhin and Leonid S. Barbarash
Int. J. Mol. Sci. 2023, 24(10), 8540; https://doi.org/10.3390/ijms24108540 - 10 May 2023
Cited by 4 | Viewed by 1545
Abstract
The lack of suitable autologous grafts and the impossibility of using synthetic prostheses for small artery reconstruction make it necessary to develop alternative efficient vascular grafts. In this study, we fabricated an electrospun biodegradable poly(ε-caprolactone) (PCL) prosthesis and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) (PHBV/PCL) prosthesis loaded with [...] Read more.
The lack of suitable autologous grafts and the impossibility of using synthetic prostheses for small artery reconstruction make it necessary to develop alternative efficient vascular grafts. In this study, we fabricated an electrospun biodegradable poly(ε-caprolactone) (PCL) prosthesis and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) (PHBV/PCL) prosthesis loaded with iloprost (a prostacyclin analog) as an antithrombotic drug and cationic amphiphile with antibacterial activity. The prostheses were characterized in terms of their drug release, mechanical properties, and hemocompatibility. We then compared the long-term patency and remodeling features of PCL and PHBV/PCL prostheses in a sheep carotid artery interposition model. The research findings verified that the drug coating of both types of prostheses improved their hemocompatibility and tensile strength. The 6-month primary patency of the PCL/Ilo/A prostheses was 50%, while all PHBV/PCL/Ilo/A implants were occluded at the same time point. The PCL/Ilo/A prostheses were completely endothelialized, in contrast to the PHBV/PCL/Ilo/A conduits, which had no endothelial cells on the inner layer. The polymeric material of both prostheses degraded and was replaced with neotissue containing smooth-muscle cells; macrophages; proteins of the extracellular matrix such as type I, III, and IV collagens; and vasa vasorum. Thus, the biodegradable PCL/Ilo/A prostheses demonstrate better regenerative potential than PHBV/PCL-based implants and are more suitable for clinical use. Full article
(This article belongs to the Special Issue Tissue Engineering of the Heart and Blood Vessels)
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17 pages, 6171 KiB  
Article
Endothelial Cell Behavior and Nitric Oxide Production on a-C:H:SiOx-Coated Ti-6Al-4V Substrate
by Igor A. Khlusov, Alexander S. Grenadyorov, Andrey A. Solovyev, Vyacheslav A. Semenov, Maksim O. Zhulkov, Dmitry A. Sirota, Aleksander M. Chernyavskiy, Olga V. Poveshchenko, Maria A. Surovtseva, Irina I. Kim, Natalya A. Bondarenko and Viktor O. Semin
Int. J. Mol. Sci. 2023, 24(7), 6675; https://doi.org/10.3390/ijms24076675 - 03 Apr 2023
Cited by 1 | Viewed by 1292
Abstract
This paper focuses on the surface modification of the Ti-6Al-4V alloy substrate via a-C:H:SiOx coating deposition. Research results concern the a-C:H:SiOx coating structure, investigated using transmission electron microscopy and in vitro endothelization to study the coating. Based on the analysis of [...] Read more.
This paper focuses on the surface modification of the Ti-6Al-4V alloy substrate via a-C:H:SiOx coating deposition. Research results concern the a-C:H:SiOx coating structure, investigated using transmission electron microscopy and in vitro endothelization to study the coating. Based on the analysis of the atomic radial distribution function, a model is proposed for the atomic short-range order structure of the a-C:H:SiOx coating, and chemical bonds (C–O, C–C, Si–C, Si–O, and Si–Si) are identified. It is shown that the a-C:H:SiOx coating does not possess prolonged cytotoxicity in relation to EA.hy926 endothelial cells. In vitro investigations showed that the adhesion, cell number, and nitric oxide production by EA.hy926 endothelial cells on the a-C:H:SiOx-coated Ti-6Al-4V substrate are significantly lower than those on the uncoated surface. The findings suggest that the a-C:H:SiOx coating can reduce the risk of endothelial cell hyperproliferation on implants and medical devices, including mechanical prosthetic heart valves, endovascular stents, and mechanical circulatory support devices. Full article
(This article belongs to the Special Issue Tissue Engineering of the Heart and Blood Vessels)
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Review

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30 pages, 8565 KiB  
Review
Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices
by Maria A. Rezvova, Kirill Y. Klyshnikov, Aleksander A. Gritskevich and Evgeny A. Ovcharenko
Int. J. Mol. Sci. 2023, 24(4), 3963; https://doi.org/10.3390/ijms24043963 - 16 Feb 2023
Cited by 9 | Viewed by 7490
Abstract
The development of a novel artificial heart valve with outstanding durability and safety has remained a challenge since the first mechanical heart valve entered the market 65 years ago. Recent progress in high-molecular compounds opened new horizons in overcoming major drawbacks of mechanical [...] Read more.
The development of a novel artificial heart valve with outstanding durability and safety has remained a challenge since the first mechanical heart valve entered the market 65 years ago. Recent progress in high-molecular compounds opened new horizons in overcoming major drawbacks of mechanical and tissue heart valves (dysfunction and failure, tissue degradation, calcification, high immunogenic potential, and high risk of thrombosis), providing new insights into the development of an ideal artificial heart valve. Polymeric heart valves can best mimic the tissue-level mechanical behavior of the native valves. This review summarizes the evolution of polymeric heart valves and the state-of-the-art approaches to their development, fabrication, and manufacturing. The review discusses the biocompatibility and durability testing of previously investigated polymeric materials and presents the most recent developments, including the first human clinical trials of LifePolymer. New promising functional polymers, nanocomposite biomaterials, and valve designs are discussed in terms of their potential application in the development of an ideal polymeric heart valve. The superiority and inferiority of nanocomposite and hybrid materials to non-modified polymers are reported. The review proposes several concepts potentially suitable to address the above-mentioned challenges arising in the R&D of polymeric heart valves from the properties, structure, and surface of polymeric materials. Additive manufacturing, nanotechnology, anisotropy control, machine learning, and advanced modeling tools have given the green light to set new directions for polymeric heart valves. Full article
(This article belongs to the Special Issue Tissue Engineering of the Heart and Blood Vessels)
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