Special Issue "T Lymphocytes Biology, Pathogenesis and Therapeutic Applications"
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 16691
Interests: immune response; cytotoxic T cells; B cells; antibodies; autoantibodies; cytokines; antibody dependent cytotoxicity; pathogen associated molecular patterns; pathogen recognition receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Molecular Mechanisms of an Aberrant Specific Immune Response: Role in Pathogenesis of Infectious, Autoimmune Diseases and Cancer
Special Issue in International Journal of Molecular Sciences: The Role of Cytokines in Diseases
T lymphocytes play a key role in developing adaptive immune responses. Their interaction with various subsets of leukocytes is essential for initiating an immune response, maintaining long-term immunity, as well as regulating immune responses. T lymphocyte proliferation and maintenance are supervised by cytokines, chemokines, and growth factors. Failure to control T lymphocyte proliferation and development could lead to autoimmunity and cancer. Therefore, correcting T lymphocyte function is a popular therapeutic approach aiming to restore T lymphocyte efficacy in autoimmunity and cancers. This includes using T cell expression of the TCR gene with defined specificity for cancer treatment. Monoclonal antibodies are also used for treating T cell leukemia. In recent studies, CAR-T cells demonstrated dramatic efficacy in treating hematological malignancies.
This Special Issue will compile the most recent advances in the field, with an emphasis on enhancing the development of cutting-edge strategies aimed to identify the mechanisms regulating activation, proliferation, and development of T lymphocytes. We especially welcome studies identifying novel T lymphocyte markers for disease diagnosis and treatment. Scientists are invited to submit their original research papers, case reports, clinical trials, and review articles with the following potential list of topics:
- Mechanisms of T lymphocytes development, activation, and function in health and pathologies;
- The role of cytokines, chemokines, and growth factors in the regulation of T lymphocyte function in health and pathologies;
- Gene, cell, and gene-cell technologies as the way to regulate T lymphocyte function and deliver therapeutic results;
- Novel markers and approaches for diagnosis and T lymphocyte dysfunction;
- Novel therapeutic approaches targeting T lymphocytes;
- T cell targeting vaccines.
Dr. Svetlana Khaiboullina
Dr. Svetlana Khaiboullina
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- T lymphocyte