ijms-logo

Journal Browser

Journal Browser

Thyroid Hormones and NAFLD: New Insights 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 6706

Special Issue Editor

Department of Clinical Medicine and Surgery, University of Naples Federico II | UNINA , Naples, Italy
Interests: nonalcoholic fatty liver disease; metabolic syndrome; obesity; atherosclerosis and NAFLD; PCOS and NAFLD; HCV-related chronic hepatitis; HCV-related arthritis; therapy of liver cirrhosis; portal hypertension; hepatic encephalopathy; imaging-ultrasonography of liver and spleen; psoriatic arthritis and NAFLD; cytokines in obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Thyroid hormones (TH) control several metabolic activities related to anabolism or catabolism of carbohydrates, proteins, and lipids in order to maintain homeostasis under different physiological conditions. Imbalance of TH levels in the body is associated with multiple chronic diseases, including diabetes mellitus, cardiovascular disease, and liver-related disorders. Recent research provides strong evidence that both overt hypothyroidism and subclinical hypothyroidism are associated, among others, with cardiovascular disease and chronic kidney disease, illnesses often present in patients suffering from advanced forms of NAFLD, the reason many researchers have drawn special attention to the association between TH and NAFLD. Accordingly, a number of observational studies have suggested a strong correlation between hypothyroidism and NAFLD, though there are also studies pointing out that there is no correlation.

Prof. Dr. Giovanni Tarantino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • THS levels
  • Subclinical hypothyroidism
  • Overt hypothyroidism
  • Independent risk factor
  • Thyroid function parameters in NAFLD patients
  • Liver cancer
  • Replacement therapy in NAFLD
  • Metabolic syndrome
  • Cytokines levels
  • ROS and lipid per oxidation

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 713 KiB  
Review
Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD
by Maria Mavromati and François R. Jornayvaz
Int. J. Mol. Sci. 2021, 22(23), 12797; https://doi.org/10.3390/ijms222312797 - 26 Nov 2021
Cited by 26 | Viewed by 5960
Abstract
Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of [...] Read more.
Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. The prevalence of NAFLD in the western world is increasing, and evidence of its association with hypothyroidism is accumulating. Since hypothyroidism has been identified as a modifiable risk factor of NAFLD and recent data provides evidence that selective thyroid hormone receptor β (THR-β) agonists are effective in the treatment of dyslipidemia and NAFLD, interest in potential therapeutic options for NAFLD targeting these receptors is growing. In this review, we summarize current knowledge regarding clinical and molecular data exploring the association of hypothyroidism, dyslipidemia and NAFLD. Full article
(This article belongs to the Special Issue Thyroid Hormones and NAFLD: New Insights 2.0)
Show Figures

Figure 1

Back to TopTop