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Special Issue "Circulatory System Esterases and Their Physiologic Roles in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 108

Special Issue Editor

Special Issue Information

Dear Colleagues,

The esterases present in the circulatory system hydrolyse ester groups from a large variety of compounds with different molecular weights and lipophilicities that are present in blood as part of body homeostasis or that can appear transiently in circulation due to diet, different disfunctions, or diseases. Since alcohol and acid products are more polar than the parent ester, the action of circulatory esterases generates species with an increased water solubility as compared with the parent ones, speeding up the clearance of potentially harmful lipophilic esters from circulation. A plethora of circulatory system esterases, either present in blood/plasma, attached on the blood vessel walls or contained into various cells present in the bloodstream, ensures the efficient hydrolysis of ester groups in individual compounds or in supramolecular assemblies present in this environment. In this Special Issue, we are encouraging contributions detailing the structure, mechanism of action and physiologic role of different circulatory system esterases, relevance to various diseases, and their activity modulation (inhibition/activation) for therapeutic purposes. The impact of circulatory esterases on the pharmacokinetic of drugs, prodrugs, and drug delivery systems constitutes another focus area of this Special Issue.

Prof. Dr. Marc A. Ilies
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • esterases and lipases
  • circulatory system
  • blood, plasma, blood vessels, and figurative elements of blood
  • physiopathology
  • structure and catalysis mechanism
  • substrate selectivity
  • activity assays
  • inhibition and activation
  • drugs in clinical use and under development
  • prodrugs
  • drug delivery systems
  • drug pharmacokinetics
  • toxicity and detoxification

Published Papers

This special issue is now open for submission.
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