Journal Browser

Journal Browser

Application of Biomolecular Materials in Tissue Engineering

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1206

Special Issue Editor

E-Mail Website
Guest Editor
Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary
Interests: biomolecular materials; tissue engineering; material science; in vitro and in vivo biodegradation; medical device development

Special Issue Information

Dear Colleagues, 

The current research topic encompasses material science, basic research, applied research, methodology, and application-based investigations. The main focus is on exploring biomolecular materials, which may have in vitro or in vivo applications and can be biocompatible, biomimetic or biodegradable, thus allowing the material or method to be in the direct vicinity of biological systems or cells for a longer period of time. 

The used materials can be either synthetic or natural, e.g., collagen and its derivatives, elastin, cellulose, hyaluronic acid, poly-lactic-co-glycolic acid (PLGA), poly-vinyl alcohol (PVA), poly-caprolactone (PCL), poly-ethylene glycol (PEG), poly-lactic acid (PLA) or the derivatives or composites thereof. 

In the scope of the present Special Issue, tissue engineering ultimately denotes enabling remodeling or regaining the function of a tissue or organ in a living system with the use of a filler, implant, grafting material, artificial tendons, etc. 

Artificial organs and tissues can include bone, tendon, joint, skin, or cornea. The preferred topics for this issue include (but are not limited to): 

  • Experiments based on cell culture: e.g., in vitro investigations including sustained or controlled release, biocompatibility, toxicity testing, and drug delivery.
  • Animal models, including in vivo experiments describing the restoration of function, the replacement of tissues and organs, enhancing regeneration, reducing inflammation, etc.
  • Descriptions of theoretical regenerative models, degradation modelling, nanoscale applications, or 3D-printed materials.
  • Industrial applications covering quality management, regulation, patenting, development, usability, and practical applications.

Original articles, reviews, mini-reviews, methodological articles will be eligible for consideration.

Dr. István Hornyák
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biomolecular materials
  • tissue engineering
  • material science
  • in vitro and in vivo biodegradation
  • cell culture
  • tissue regeneration
  • cell scaffold
  • biocompatible materials

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


15 pages, 2110 KiB  
Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development
by Viktória Varga, László Smeller, Róbert Várdai, Bence Kocsis, Ibolya Zsoldos, Sara Cruciani, Renzo Pala and István Hornyák
Int. J. Mol. Sci. 2024, 25(8), 4336; https://doi.org/10.3390/ijms25084336 - 14 Apr 2024
Viewed by 997
In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, [...] Read more.
In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v/v crosslinker concentration. Moreover, stress–strain and compression characteristics of the 5% v/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization. Full article
(This article belongs to the Special Issue Application of Biomolecular Materials in Tissue Engineering)
Show Figures

Graphical abstract

Back to TopTop