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Metabolic Bone Diseases: Molecular Mechanisms and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 331

Special Issue Editors

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Guest Editor
1. Department of Medical Biotechnology and Translational Medicine, University of Milan, 20122 Milan, Italy
2. Unit of Endocrinology, ASST Ospedale Niguarda, 20162 Milan, Italy
Interests: adrenal diseases; parathyroid diseases; osteoporosis; metabolic bone diseases; endocrine hypertension
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Unit for Bone Metabolism Diseases and Diabetes, Istituto Auxologico Italiano, IRCCS, 20149 Milan, Italy
Interests: primary and secondary osteoporosis; endocrinopathies; hormone therapy; metabolic bone diseases; calcium-phosphorus metabolism disorders; rare skeletal diseases

Special Issue Information

Dear Colleagues,

Metabolic bone diseases encompass a wide range of clinical conditions that are both common, such as osteoporosis, primary and secondary hyperparathyroidism; and rare, such as oncogenic osteomalacia, osteogenesis imperfecta, hypophosphatasia and other genetic skeletal disorders.

This Special Issue aims to investigate the molecular mechanisms underlying the pathogenesis of metabolic bone diseases. Indeed, the identification of novel signaling pathways could unmask new drug targets which, in turn, could increase our therapeutic strategies. Moreover, the discovery of new mechanisms could help to predict the response to treatments and thus to personalize the clinical management of patients with metabolic bone disorders in the context of tailored medicine.

Therefore, this Special Issue will welcome the submission of both original articles, based on basic or translational research, and review papers, targeting the scientific innovations in the field of metabolic bone diseases.

Dr. Iacopo Chiodini
Dr. Elisa Cairoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bone metabolism
  • osteoclasts
  • osteoblasts
  • osteocytes
  • drug targets
  • signaling pathways

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Alterations in phosphate metabolism in patients with Klinefelter’s syndrome
Author: Indirli
Highlights: - Subjects with Klinefelter syndrome display persistent/recurrent hypophosphatemia in a proportion as high as 1 in 10. - An increased phosphate urinary loss may be responsible for this finding. - Hypophosphatemia is not associated with skeletal fragility, which is frequently observed in Klinefelter syndrome.

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