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Perivascular Adipose Tissue and Protease-Activated Receptor 2 (PAR2): Molecules and Signalling in Metabolic Syndrome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 202

Special Issue Editors

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Guest Editor
1. Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada
2. Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada
Interests: endothelium; vascular smooth muscle; G-protein-coupled receptors; peptides; blood vessels

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Guest Editor
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya 663 8184, Japan
Interests: perivascular adipose tissue; protease-activated receptor 2; metabolic syndrome; vascular endothelium; cardiovascular function
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Special Issue Information

Dear Colleagues,

Metabolic syndrome (MetS) increases the risk of heart, blood vesel, kidney and cerebrovascular diseases. Furthermore obesity, type 2 diabetes and lipidemia associated with MetS affect the adipose tissue surrounding visceral organs and blood vessels, i.e., perivascular adipose tissue (PVAT). Bioactive substances, for example, metabolites, adipokines, proteases and gaseous transmitters generated by PVAT are known to modulate circulatory system function, including local vascular tone and wall remodeling, and contribute to cardiac and vascular complications. Studies in various animal models provide evidence that cell receptors such as the G-protein-coupled receptor protease-activated receptor 2 (PAR2) participate in the inflammatory pathological conditions of MetS and obesity. Thus, PVAT can be a source and target of molecular signals in health and disease.

This Special Issue will look at the characterizations of the molecules and signaling underpining the roles played by PVAT in MetS. Studies elaborating on the theme of protease-activated receptor 2 are particularly encouraged. We welcome original research articles and reviews covering the research areas, especially preclinical models and novel molecules, focused on therapeutics. We hope this Special Issue provides insights into the molecular signaling and function of PVAT and opportunities for discussion of new approaches to the prevention and treatment of MetS complications.

Dr. John J. McGuire
Dr. Satomi Kagota
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • perivascular adipose tissue
  • protease-activated receptor 2
  • metabolic syndrome
  • inflammations
  • adipokines

Published Papers

This special issue is now open for submission.
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