Special Issue "Protein Function and Protein Structure"
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 366
The recent CoV-2 pandemic, as well as long known viral infections such as influenza, shows the close relationship between small structural changes through mutation, generating new variants with which science and vaccination must keep up, as well as necessitating efficient detection of the new variant for diagnosis and choosing the best possible therapy. The focus of this Special Issue will be on the effects of mutations on the overall protein structure and the change in functionality in the field of infection research, particularly the mutations leading to possible escape mechanisms for either the immune system or therapeutic strategies. Therefore, we focus (1) on viral surface proteins, virus-like particles and membrane proteins, all of which are involved in virus–cell interactions; (2) the role glycosylation and possibly other post-translational modifications play in cellular recognition, either to fight against the virus via proteins and cells from the immune system or the mode of action of the virus to recruit cells for their own survival and spread to new hosts; (3) the best way to generate high-quality recombinant material for studying both the structure as well as the biological function of the protein; and (4) the tools, technologies and strategies required to investigate these important interaction partners in infection processes. We encourage the submission of research on protein variants or homologues showing differences in structure and function, including experimental proof of the mechanism and mode of action.
Dr. Joop Van Den Heuvel
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