Special Issue "Advances in Understanding Lipases and Lipid Metabolism"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 25 June 2024 | Viewed by 1012
Special Issue Editor
Dr. Monika Oberer
Interests: lipase; proteins; enzymology and structural biology of lipases, biophysics; triacylglycerol lipases; protein-protein interaction; lipid metabolism; ATGL; ABHD5; MG; carboxylesterases; lipolytic regulation; protein crystallography; NMR spectroscopy; intrinsically disordered regions; protein dynamics; biophysics; structure-function relationship of proteins; modulation of enzyme activity
Special Issue Information
Dear Colleagues,
Living organisms must adapt to changes in external energy availability, and the integration of dynamic storage organelles termed lipid droplets has proven to be a successful evolutionary concept to maintain cellular energy homeostasis. Lipid droplets are generated when there is an excess of energy and are utilized during times of energy deprivation. They tightly package triacylglycerol and sterol esters, which are enclosed by a phospholipid monolayer furnished with various proteins. The growing lipid droplet represents the transition from the membrane lipid bilayer at the endoplasmic reticulum membrane to an independent organelle, whereas lipid droplets shrink upon hydrolytic consumption of the stored high energy substrates. This requires a finely tuned balance between anabolic (lipogenesis) and catabolic (lipolysis) processing of lipids. Proteins involved in neutral lipolysis, acid lipolysis, and lipogenesis act as lipases, acyl-transferases, general regulators, co-activators, and inhibitors. Recent studies have discovered that lipases often also exert additional anabolic functions, particularly in transacylation processes. Abnormal processing of lipids is associated with various metabolic diseases, including insulin resistance, type 2 diabetes, lipid storage diseases, non-alcoholic fatty liver disease, cancer cachexia, and aberrant lipid signaling. Lipases produced from pathogenic bacteria can promote the success of bacterial infections by facilitating bacterial invasion, growth, and immune evasion. This special section discusses intracellular activities and interactions between proteins, lipids, and lipid droplets in lipid metabolism under both normal physiological and pathological conditions.
Dr. Monika Oberer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid hydrolase activity
- lipogenesis
- metabolic disease
- lipase inhibition
- protein structure
- lipid droplet
- neutral lipolysis
- acid lipolysis
- lipophagy
- transacylation
- phospholipase
- lipase co-activation
- lipid–water interphase
- lipase-mediated pathogenesis
- lipid droplet monolayer (membrane bilayer)
