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Notch Signaling in Health and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 28 June 2024 | Viewed by 1356

Special Issue Editors

Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, 34137 Trieste, Italy
Interests: cell biology; apoptosis; keratinocytes; keratinocytes differentiation; keratinocytes proliferation; notch signaling; dermatology diseases
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Special Issue Information

Dear Colleagues, 

This Special Issue is a continuation of our previous Special Issue “Notch Signaling in Health and Disease”.

Notch signaling plays a crucial role in various cellular processes, such as proliferation, differentiation, migration, cellular fate, and death, during both normal development and in those with pathological conditions.

Notch signaling controls the induction of keratinocyte growth, promotes the activation of the differentiation program, and is also involved in the regulation of inflammatory responses. Alterations and hyper- or hypo-activation in Notch signaling molecules and in their target genes can induce failure in the regulation of keratinocyte functions, which, in turn, produces skin diseases.

The pathogenetic role of the Notch pathway in skin diseases is not currently fully understood. In recent years, attention has been focused on the correlation between Notch signaling and skin diseases; Notch signaling alterations have recently been reported for the following five human skin diseases, suggesting the involvement of Notch in their pathogenesis: hidradenitis suppurativa, Dowling–Degos disease, Adams–Oliver syndrome, psoriasis, and atopic dermatitis.

This Special Issue is dedicated to the role of Notch signaling in health and skin diseases. Areas of particular interest include but are not limited to defects in keratinocytes and skin health and diseases, autoinflammatory keratinization diseases, and Notch signaling regulation in health and skin diseases.

Dr. Paola Maura Ticarico
Prof. Dr. Sergio Crovella
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatological diseases
  • Notch signaling
  • keratinocytes
  • inflammation
  • autoinflammation
  • differentiation
  • keratinization
  • proliferation

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Published Papers (1 paper)

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Review

17 pages, 1293 KiB  
Review
Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders
by Joanna Kałafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Müller and Lidia Borkiewicz
Int. J. Mol. Sci. 2023, 24(16), 12579; https://doi.org/10.3390/ijms241612579 - 08 Aug 2023
Cited by 1 | Viewed by 1011
Abstract
Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at [...] Read more.
Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at the transcriptional level but also by a variety of post-translational events. First is the ligand-dependent mechanical activation of NOTCH receptors and then the intracellular crosstalk with other signalling molecules—among those are long non-coding RNAs (lncRNAs). In this review, we provide a detailed overview of the specific role of lncRNAs in the modulation of Notch1 signalling, from expression to activity, and their connection with the development of health disorders, especially cancers. Full article
(This article belongs to the Special Issue Notch Signaling in Health and Disease 2.0)
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