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Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 161

Special Issue Editors

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Guest Editor
Medical Biochemistry Department, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: genetics; epigenetics; medical biochemistry; metabolic disorders

E-Mail Website
Guest Editor
Pharmaceutical Biochemistry and Clinical Laboratory Department, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: (clinical) biochemistry; medicinal chemistry; drug discovery; anticancer
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Special Issue Information

Dear Colleagues,

Metabolic syndrome (syndrome X, insulin resistance syndrome) is a multifactorial disease, with higher morbidity and mortality risk and increased frequency in younger people. It includes a cluster of risk factors for cardiovascular diseases caused by adipose tissue dysfunction and insulin resistance. Risk factors most closely tied to metabolic syndrome include age, ethnicity, a body mass index greater than 25, a personal or family history of diabetes, smoking, stress, being post-menopause, high-fat diet, a sedentary lifestyle, and hormonal imbalance. Genetic factors could influence each individual component of the syndrome and the syndrome itself. The genetic components of hypertension, obesity, dyslipidemia, oxidative stress, inflammation, cytokine hypersecretion, and epigenetic modifications should also be considered in metabolic syndrome risk factors.

According to the National Heart, Lung, and Blood Institute (NHLBI), and the American Heart Association (AHA), metabolic syndrome is diagnosed when a patient has at least three of the following five conditions: abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and a lower HDL-cholesterol level.

Metabolic syndrome greatly raises the risk of developing coronary heart disease, stroke, diabetes, fatty liver, polycystic ovarian syndrome, cholesterol gallstones, asthma, sleep problems, and several types of cancer.

This Special Issue will include original research, case reports, and review papers investigating the biochemical, genetic, and epigenetic biomarkers related to the risk of developing metabolic syndrome in order to elucidate the pathogenic mechanism. Furthermore, this Special Issue will consider in silico, experimental in vitro, and in vivo studies with higher potential to improve the management (prevention, diagnosis, and treatment) of metabolic syndrome.

Prof. Dr. Lucia Maria Procopciuc
Prof. Dr. Roxana Liana Lucaciu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • insulin resistance
  • hypertension
  • diabetes mellitus
  • obesity
  • inflammation
  • stress
  • metabolic disorders
  • reproductive endocrine disorders
  • polycystic ovarian syndrome
  • waist circumference
  • estrogen deficiency
  • disturbances in adipose tissue
  • physical inactivity
  • overnutrition
  • cardiovascular diseases
  • abdominal obesity
  • genetics and epigenetics of metabolic syndrome
  • computational analysis

Published Papers

This special issue is now open for submission.
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