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Special Issue "Structure and Interaction of Bioactive Peptides with Lipid and Bio-Membranes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 416

Special Issue Editor

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia
Interests: cobra venom; proteomics; cytolytic peptides; antiproliferative activity; structure-functional relationship; antimicrobial peptide; template-based design of bioactive peptides; lipid/peptide interactions; apoptosis; action synergism
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Special Issue Information

Dear Colleagues,

Membrane-active peptides (MAPs) are produced by various organisms that inhabit both plant and animal kingdoms. MAPs are attractive objects as lead compounds in the design of new antibacterial, anticancer, antifungal, and antiviral bioactive peptides. The general task is to design highly active compounds, considering the natural MAPs as a template. In the first approximation, this can be carried out, assuming the lipid composition of the target membrane is known. However, biopolymers residing next to the lipid bilayer in living cells are able to influence the activity of peptides. Thus, interaction between the designed peptides and the components of bio-membranes must be taken into account, too. The current Special Issue is devoted to elucidating the efforts on improving the activity of natural MAPs with different origins. Both experimental works and computer studies that deal with either model membrane systems, living cells, or their surrogates are welcome. The potential works should answer the questions: how can natural MAPs be modified to increase their bioactivity and selectivity, and what molecular mechanism underlies such activities? As an alternative, the rows of natural MAPs and structure-activity relationships within them can be rationalized, too. Reviews that deal with certain classes of MAPs and their mechanism of bioactivity are another possibility.

Dr. Peter V. Dubovskii
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • membrane-active peptides
  • lipid/peptide interactions
  • biomembranes
  • biological activity
  • peptide engineering
  • structure–functional relationships
  • therapeutic index

Published Papers

There is no accepted submissions to this special issue at this moment.
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