Special Issue "Structure and Interaction of Bioactive Peptides with Lipid and Bio-Membranes"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 416
Special Issue Editor
Interests: cobra venom; proteomics; cytolytic peptides; antiproliferative activity; structure-functional relationship; antimicrobial peptide; template-based design of bioactive peptides; lipid/peptide interactions; apoptosis; action synergism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Membrane-active peptides (MAPs) are produced by various organisms that inhabit both plant and animal kingdoms. MAPs are attractive objects as lead compounds in the design of new antibacterial, anticancer, antifungal, and antiviral bioactive peptides. The general task is to design highly active compounds, considering the natural MAPs as a template. In the first approximation, this can be carried out, assuming the lipid composition of the target membrane is known. However, biopolymers residing next to the lipid bilayer in living cells are able to influence the activity of peptides. Thus, interaction between the designed peptides and the components of bio-membranes must be taken into account, too. The current Special Issue is devoted to elucidating the efforts on improving the activity of natural MAPs with different origins. Both experimental works and computer studies that deal with either model membrane systems, living cells, or their surrogates are welcome. The potential works should answer the questions: how can natural MAPs be modified to increase their bioactivity and selectivity, and what molecular mechanism underlies such activities? As an alternative, the rows of natural MAPs and structure-activity relationships within them can be rationalized, too. Reviews that deal with certain classes of MAPs and their mechanism of bioactivity are another possibility.
Dr. Peter V. Dubovskii
Guest Editor
Manuscript Submission Information
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Keywords
- membrane-active peptides
- lipid/peptide interactions
- biomembranes
- biological activity
- peptide engineering
- structure–functional relationships
- therapeutic index
