ijms-logo

Journal Browser

Journal Browser

Fatty Acid Oxidation in Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 544

Special Issue Editor


E-Mail Website
Guest Editor
Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
Interests: isoprostanes; neuroprostanes; markers of oxidative stress; oxidative stress in human diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The oxidative metabolism of fatty acids plays a crucial role in the regulation of pathophysiological processes, both as enzymatic and non-enzymatic oxidation.

Pro-inflammatory and anti-inflammatory pro-resolving lipid mediators, biomarkers of oxidative lipid damage and the supplementation of omega-6 and omega-3 fatty acids, are of great interest for the diagnosis and treatment of diseases affecting different systems.

Therefore, targeted monitoring of fatty acid oxidation is an important issue in molecular diagnosis and assessment of disease progression and clinical severity.

The Special Issue is open to topics on signaling pathways, biomarkers and modulation of fatty acid oxidation in disease. The submission of high-quality papers on human disease and animal model studies is encouraged. Both original research articles and reviews on these topics are welcome. It is worth noting that the International Journal of Molecular Sciences encourages the inclusion of results at the molecular level.

Dr. Cinzia Signorini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fatty acid oxidation
  • inflammation
  • lipid mediators
  • lipid metabolism
  • omega-3 fatty acids
  • oxidative stress
  • dietary supplementation
  • animal models
  • human diseases

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 3434 KiB  
Article
Olive Flounder By-Product Prozyme2000P Hydrolysate Ameliorates Age-Related Kidney Decline by Inhibiting Ferroptosis
by Myeongjoo Son, You-Jin Jeon, Bomi Ryu and Dae Yu Kim
Int. J. Mol. Sci. 2024, 25(9), 4668; https://doi.org/10.3390/ijms25094668 - 25 Apr 2024
Viewed by 403
Abstract
This study explores olive flounder by-product Prozyme2000P (OFBP) hydrolysate as a potential treatment for age-related kidney decline. Ferroptosis, a form of cell death linked to iron overload and oxidative stress, is increasingly implicated in aging kidneys. We investigated whether OFBP could inhibit ferroptosis [...] Read more.
This study explores olive flounder by-product Prozyme2000P (OFBP) hydrolysate as a potential treatment for age-related kidney decline. Ferroptosis, a form of cell death linked to iron overload and oxidative stress, is increasingly implicated in aging kidneys. We investigated whether OFBP could inhibit ferroptosis and improve kidney health. Using TCMK-1 cells, we found that OFBP treatment protected cells from ferroptosis induced by sodium iodate (SI). OFBP also preserved the mitochondria health and influenced molecules involved in ferroptosis regulation. In aging mice, oral administration of OFBP significantly improved kidney health markers. Microscopic examination revealed reduced thickening and scarring in the kidney’s filtering units, a hallmark of aging. These findings suggest that OFBP hydrolysate may be a promising therapeutic candidate for age-related kidney decline. By inhibiting ferroptosis, OFBP treatment appears to improve both cellular and structural markers of kidney health. Further research is needed to understand how OFBP works fully and test its effectiveness in more complex models. Full article
(This article belongs to the Special Issue Fatty Acid Oxidation in Diseases)
Show Figures

Figure 1

Back to TopTop