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Special Issue "Nano for Health: Strategies and Challenges of Nanotechnology for Drug Delivery"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 28 February 2024 | Viewed by 56

Special Issue Editors

Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
Interests: topical drug delivery; tissue engineered skin substitutes; natural products in drug discovery
1. Research Institute for Medicines, iMed.ULisboa—Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal
2. Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, Universidade de Lisboa, 1649-003 Lisboa, Portugal
Interests: development of new drug delivery systems; therapeutic polymers for drug delivery; methods of micro- and nanoencapsulation of drugs
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Special Issue Information

Dear Colleagues,

Nanotechnology has become an excellent platform with many applications in different fields of science, allowing us to control and manipulate matter at the nanoscale by designing and engineering new systems. In the health field, nanotechnology has been shown to be an optimal solution to improve the effectiveness of different drugs. An established strategy for drug delivery consists of encapsulating the drugs in a suitable nanocarrier system. As a result, there is an increased therapeutic index by controlling the rate and site of drug release, solubility and stability. Moreover, nanocarriers can extend a formulation’s action and successfully combine active substances with different degrees of hydrophilicity. However, there also are some associated challenges. Many drug delivery systems lack knowledge of their molecular mechanisms of interaction with the cell. In addition, there is a need for a better characterization and understanding of toxicity issues since the actual knowledge about the fate of nanocarriers is still insufficient. Moreover, the pharma industry is still facing a lack of specific regulation and the cost/benefit ratio needs to be considered and analyzed in each case. Finally, there is also a challenge in the scale-up of nanoparticle manufacturing due to the variety of possible formulations and combinations of nanomaterials.

This Special Issue aims to investigate nanocarrier–drug–tissue interactions. It will focus on how nanocarriers' complex structure influences therapeutic activity and further explore the interactions with the target and mechanism of transport. This issue will also cover the main challenges associated with the production and characterization of these nanocarriers.

Dr. Dragana Barros
Dr. Catarina Pinto Reis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanotechnology
  • drug delivery
  • therapeutic and diagnostics nanoplatforms
  • cell interaction
  • toxicity
  • biodistribution
  • pharmacokinetics
  • in vitro and in vivo models
  • in silico models
  • scale-up manufacturing
  • regulatory framework

Published Papers

This special issue is now open for submission.
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