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Special Issue "Recent Advances of HDL: Inflammation and Longevity"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 116

Special Issue Editor

Special Issue Information

Dear Colleagues,

Hyperinflammation is intricately associated with the cytokine cascade of coronavirus disease-19 (COVID-19), resulting in acute death and chronic pain in individuals suffering from autoimmune diseases, rheumatoid arthritis (RA), psoriasis, and sepsis. The production of dysfunctional high-density lipoproteins (HDLs) can aggravate the inflammatory response, even though native HDL exerts antioxidant and anti-inflammatory activity. Indeed, native HDLs kill SARS-CoV2 via adequate paraoxonase activity.

Aging is a chronic process that involves several physical and biochemical modifications that affect HDL structure and function; this includes nonenzymatic glycation, which produces advanced glycated end products (AGEs). Aging is accompanied by an increase in circulating proinflammatory cytokines and acute-phase reac­tants such as interleukin-6, Serum Amyloid A and C-reactive protein. It has been established that when aging occurs, there is a decline in serum antioxidant activity, a cleavage of apoA-I, an increase in CETP activity, a reduction in the HDL particle size, an increase in SAA and apoC-III content in lipoproteins, and a pro-inflammatory change in the serum lipid profile.

HDLs possess many beneficial qualities and functionalities that prevent infection, inflammation, and the incidence of aging-related diseases, such as autoimmune diseases, cardiovascular diseases, diabetes, and dementia.

This Special Issue welcomes contributions that focus on the correlations between HDL quality, inflammation, and longevity in various stages of health, and the application of HDL-associated apolipoproteins and enzymes as therapeutic tools.

Prof. Dr. Kyung-Hyun Cho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • high-density lipoproteins (HDL)
  • inflammation
  • longevity
  • aging
  • apoA-I

Published Papers

This special issue is now open for submission.
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