Special Issue "Nitroreductases and Nitro-Reduction"
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3459
Interests: flavoenzyme catalysis; quinones; nitroaromatics; aromatic N-oxides; polyphenolic antioxidants; mechanisms of cytotoxicity
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Nitroaromatic compounds with worldwide production of up to 108 tons per year maintain their importance in relation to industrial processes, military activities, environmental pollution, and pharmaceutical application. Because of the contamination of groundwater and soil at military and industrial sites by nitroaromatics, that exhibit toxic, mutagenic, and cancerogenic activities, there has been a significant increase in research to understand and apply biological processes for their degradation. On the other hand, the electron-attracting ability and redox activity make the nitro group a versatile group in medicinal chemistry. Nitroaromatic compounds have a long history of use as antibacterial and antiparasitic drugs, radiosensitizers, and hypoxia-selective anticancer agents. Importantly, both the biodegradation of nitroaromatic environmental pollutants and the manifestation of toxicity/therapeutic action of nitroaromatic drugs may involve similar initial reduction steps, performed by various flavoenzymes and/or their physiological redox partners, metalloproteins. However, in spite of the rapidly increasing amount of information in this area, the still incompletely resolved questions are the identification, characterization and optimization of the specific enzymes that are involved in the bioreduction of nitroaromatics and their reaction mechanisms.
This Special Issue invites research findings and reviews of recent works which share updates on and enrich our knowledge nitroreductases and related enzymes. The Special Issue targets research on a molecular to cellular level: reaction intermediates, electron/hydride transfer reactions, substrate recognition, structure–function relation, environmental and therapeutic application utilizing spectroscopic, kinetic, and structural analyses, computational science, genomics, proteomics, and metabolomics approaches. We believe that this Special Issue, “Nitroreductases and Nitroreduction”, will help to highlight the most recent advances in this field.
We look forward to your contribution.
Prof. Dr. Narimantas K. Cenas
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- substrate recognition
- physiological redox partners