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Special Issue "Molecular Mechanisms of Ischemia/Reperfusion"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 11241
Special Issue Editor
Interests: trauma-and-hemorrhage; traumatic brain injury; septic shock
Special Issue Information
Ischemia/reperfusion sequences contribute to morbidity and mortality during various critical illnesses, both in surgical and medical contexts. They are characterized by an initial imbalance between metabolic supply and demand, resulting in profound tissue hypoxia with hypoxia-related inflammation and excess formation of reactive oxygen and nitrogen species, and subsequent reperfusion, which further aggravates both hyperactivation of the immune response, oxidative and nitrosative stress, and cell death programs. New advances in the understanding of the molecular, metabolic and immunological consequences of ischemia/reperfusion sequences may allow us to develop innovative therapeutic strategies to limit or even prevent the often-occurring subsequent organ dysfunction in patients experiencing this clinical condition.
The aim of this Special Issue is to collect high-quality research and review articles focusing on the molecular mechanisms and innovative therapeutic strategies related to all kinds of ischemia/reperfusion sequences in the context of both “low” and/or even “no flow” conditions, and subsequent restoration of blood flow, as well as hypoxia and re-oxygenation. A special focus will be paid to trauma and hemorrhage and resuscitation. However, articles related to other kinds of ischemia/reperfusion are welcome, e.g., aortic cross clamping, restoration of spontaneous circulation after cardiac arrest, cardiopulmonary bypass, organ transplantation, myocardial infarction and ischemic stroke.
Since IJMS is a journal of molecular science, pure clinical studies will not be suitable; however, clinical submissions including biomolecular experiments focusing on the above-mentioned topics are welcomed.
Prof. Dr. Peter Radermacher
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxygen radical
- nitrogen radicals
- mitochondrial dysfunction
- multi-organ failure
- massive transfusion
- acute kidney injury