Special Issue "Mesenchymal Stem Cells: Cross-Talk with the Microenvironment"
Deadline for manuscript submissions: 25 November 2023 | Viewed by 977
Interests: physiology of multipotent mesenchymal stromal cells and neural crest stem cells; non-coding RNA; genome architecture; endothelial-mesenchymal transition
Multipotent mesenchymal stromal cells (mMSC) are involved in building up the stroma of most organs. These cells are involved in bone marrow hematopoietic niche in health and disease. They are also one of the keys stromal components of solid tumor. Though mesenchymal stem cells are capable to multilineage differentiation, their main role is to fine-tune the functioning of adjacent cells. mMSC mediate the fine balance between differentiation, proliferation, self-renewal and quiescence via intracellular regulatory networks and cell-to-cell interaction. Only in concert with their specialized microenvironment they retain their unique properties. This local microenvironment is termed ‘the stem cell niche’. The interaction between mesenchymal stem cells and the surrounding cells works both ways: adjacent cells influence and are influenced by mMSC. In this Special Issue devoted to mMSC interaction with their neighborhood we will discuss recent breakthroughs in this topic and their impact on basic research and the concept of mMSC clinical application. We aim to depict recent data on our progress in understanding the mechanisms of mMSC bidirectional interaction with their microenvironment. The data will broaden our understanding of mMSC therapeutic potential and bring new ideas on possible clinical applications.
Dr. Natella Enukashvily
Dr. Anna Malashicheva
Manuscript Submission Information
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- mesenchymal stem cell niche
- cell-to-cell interaction
- tumor microenvironment
- stem cells transcriptome
- extracellular vesicles