Special Issue "Melanoma Cell Signaling Pathways"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 5471
Interests: cell signaling; melanoma; photobiology; skin cancer; cell metabolism; melaninognesis; cell motility; ionizing radiation
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Melanocytes are pigment cells found on the skin, which produce melanin in response to sunlight (UV radiation) exposure. Prolonged exposure to sunlight is the main carcinogen involved in melanoma formation. The formation of melanoma differs between different ethnic groups, with nodular melanoma, superficial spreading melanoma, and lentigo maligna melanoma predominantly seen amongst Caucasians; acral lentiginous melanoma predominates in other ethnic groups. Genomic analysis has shown that metastatic melanomas can be subdivided into four subtypes based on their mutation profile: BRAF-driven, NRAS-driven, NF1-mutated, and the rest are classified as triple wild-type. With the exception of the last subtype, all these melanomas possess mutations that affect signaling through the mitogen-activated protein kinase (MAPK) pathway. The main mutation observed in melanoma is the BRAFV600E mutation, which is found in ~50% of melanomas, but surprisingly is not caused by UV radiation. In 2011, vemurafenib was approved to treat BRAFV600E melanomas; however, the initial success of this drug was dampened by the development of acquired resistance. Since then, many studies have been conducted on how acquired resistance develops and the other signaling pathways involved in this process. This Special Issue is devoted to the investigation of signaling pathways found in melanomas (e.g., MAPK, PI3K–Akt–mTOR, GPCR, and others) how they are affected by growth factors and/or inhibitors, and to what extent cross-talk occurs between them.
Prof. Dr. Terrence Piva
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- Cell signaling