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Recent Advances in Medicinal Chemistry: Green Synthesis of Bioactive Molecules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 March 2024) | Viewed by 6617

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Napoli Federico II, 80131 Napoli, Italy
Interests: prodrug strategy; carbohydrate-based prodrugs; drug targeting; drug discovery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy
Interests: microwave-assisted organic synthesis; heterocyclic compounds; peptidomimetics; serotoninergic ligands; H2S-releasing moieties

Special Issue Information

Dear Colleagues,

Green chemistry is a discipline of great interest in medicinal chemistry. It involves all fields of chemistry and is based on the principle of conducting chemical reactions while protecting the environment at the same time, through the use of chemical procedures able to avoid pollution. Green synthetic techniques and the use of alternative energy sources as tools to obtain chemical reactions have drawn the attention of the pharmaceutical industry and academia. Greener synthetic routes to develop bioactive compounds; the use of ultrasound, microwaves, flow chemistry and other approaches for the synthesis of biologically active molecules; as well as safe transformations by degradable or recyclable reagents are necessary so that green chemistry can further provide its contribution to the quality of environmental matrices, tightly related to the good state of health of humans, thus joining in combination to the purposes of good health promoted by pharmaceutical chemistry. 

The aim of this Special Issue is to collect research articles, reviews, and perspectives illustrating the recent advances in the green synthesis of biologically active molecules, even focusing on the pharmacological use of these compounds in preclinical or application studies. As Guest Editors, we warmly invite authors working in this field to contribute their recent studies to this Special Issue of International Journal of Molecular Sciences.

Prof. Dr. Maria Grazia Rimoli
Prof. Dr. Francesco Frecentese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green synthetic approaches
  • drug discovery
  • green chemistry
  • green solvents
  • green reagents
  • bioactive molecule
  • biological applications

Published Papers (2 papers)

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Review

43 pages, 17041 KiB  
Review
The Application of Microwaves, Ultrasounds, and Their Combination in the Synthesis of Nitrogen-Containing Bicyclic Heterocycles
by Francesco Frecentese, Federica Sodano, Angela Corvino, Marica Erminia Schiano, Elisa Magli, Stefania Albrizio, Rosa Sparaco, Giorgia Andreozzi, Maria Nieddu and Maria Grazia Rimoli
Int. J. Mol. Sci. 2023, 24(13), 10722; https://doi.org/10.3390/ijms241310722 - 27 Jun 2023
Cited by 2 | Viewed by 1437
Abstract
The use of alternative energy sources, such as microwaves (MW) or ultrasounds (US), and their mutual cross-combination have been widely described in the literature in the development of new synthetic methodologies in organic and medicinal chemistry. In this review, our attention is focused [...] Read more.
The use of alternative energy sources, such as microwaves (MW) or ultrasounds (US), and their mutual cross-combination have been widely described in the literature in the development of new synthetic methodologies in organic and medicinal chemistry. In this review, our attention is focused on representative examples, reported in the literature in the year range 2013–2023 of selected N-containing bicyclic heterocycles, with the aim to highlight the advantages of microwave- and ultrasound-assisted organic synthesis. Full article
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18 pages, 11889 KiB  
Review
Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials
by Andrea Citarella, Arianna Amenta, Daniele Passarella and Nicola Micale
Int. J. Mol. Sci. 2022, 23(24), 15960; https://doi.org/10.3390/ijms232415960 - 15 Dec 2022
Cited by 7 | Viewed by 4445
Abstract
In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to a future of biocompatibility and recycling. The green solvent Cyrene, obtained from biomass via a two-step synthesis, is increasingly [...] Read more.
In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to a future of biocompatibility and recycling. The green solvent Cyrene, obtained from biomass via a two-step synthesis, is increasingly being introduced as the solvent of choice for the development of green synthetic transformations and for the production of biomaterials, thanks to its interesting biocompatibility, non-toxic and non-mutagenic properties. Our review offers an overview of the most important organic reactions that have been investigated to date in Cyrene as a medium, in particular focusing on those that could potentially lead to the formation of relevant chemical bonds in bioactive molecules. On the other hand, a description of the employment of Cyrene in the production of biomaterials has also been taken into consideration, providing a point-by-point overview of the use of Cyrene to date in the aforementioned fields. Full article
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