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Mitochondrial Proteomics in Neuroscience and Neurodegenerative Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3935

Special Issue Editors

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Univesità Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: hydrogen sulfide; metabolomics; mitochondrial biochemistry; neurodegenerative diseases; oxidative stress; proteomics; PTMs; redox dysregulation; sulfur species
Special Issues, Collections and Topics in MDPI journals
Unità di Proteomica e Metabolomica, Fondazione S. Lucia IRCCS, 00179 Roma, Italy
Interests: proteomics; mitochondrial proteomics; mitochondria biology; neurodegenerative disease; metabolism; oxidative phosphorylation; biomarkers

Special Issue Information

Mitochondria play a key role as energy mediators and in the biosynthesis of eukaryotic cells, so they are recognized as the cell’s powerhouse. In addition to this function in cellular bioenergetics, mitochondria are involved in several other pathways such as the regulation of cell death processes, the modulation of ionic homeostasis, and the oxidation of carbohydrates and fatty acids. Therefore, it is not surprising that mitochondrial dysfunctions or alterations can have a serious impact both in defects of energy metabolism and in the multifactorial diseases in which they are directly involved.

The involvement of mitochondria in the pathogenic mechanisms of neurodegenerative disorders (for example amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and Down’s syndrome) has been well established. In recent years, many efforts have been made to understand these mechanisms, especially through the advances of the omics sciences.

From this perspective, mitochondria have become a “hotspot” for subcellular proteomics, with the aim of identifying clinical targets as candidate biomarkers in neurodegenerative diseases. 

The purpose of this Special Issue is to gather the latest information and highlight the state of the art in the progress of mitochondrial proteomics in order to highlight yet-unknown aspects, or to clarify the complex mechanisms, linked to mitochondrial dysfunction in neurodegenerative diseases.

Reviews, commentaries, and original research based on proteomics and mass spectrometry are welcome (for example, discovery, quantitative aspects, PTMs, and redox proteomics), independently or in combination with other, more classic biochemical, molecular, and cellular approaches.

Dr. Viviana Greco
Dr. Luisa Pieroni
Guest Editors

Manuscript Submission Information

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Keywords

  • Proteomics
  • Mass Spectrometry
  • Mitochondria
  • Mitochondria Function
  • Neurodegeneration
  • Metabolism
  • Neuronal activity
  • Neuronal plasticity
  • Mitochondrial protein function
  • Mitochondrial protein annotation
  • OXPHOS
  • Biomarkers
  • Aging
  • Drug Target
  • Drug Repurposing
  • Knowledge Base
  • Antibodies

Published Papers (1 paper)

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Review

20 pages, 1464 KiB  
Review
Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data
by Caitlyn Mahony and Colleen O’Ryan
Int. J. Mol. Sci. 2021, 22(19), 10757; https://doi.org/10.3390/ijms221910757 - 05 Oct 2021
Cited by 11 | Viewed by 3084
Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with extensive genetic and aetiological heterogeneity. While the underlying molecular mechanisms involved remain unclear, significant progress has been facilitated by recent advances in high-throughput transcriptomic, epigenomic and proteomic technologies. Here, we review recently published [...] Read more.
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with extensive genetic and aetiological heterogeneity. While the underlying molecular mechanisms involved remain unclear, significant progress has been facilitated by recent advances in high-throughput transcriptomic, epigenomic and proteomic technologies. Here, we review recently published ASD proteomic data and compare proteomic functional enrichment signatures with those of transcriptomic and epigenomic data. We identify canonical pathways that are consistently implicated in ASD molecular data and find an enrichment of pathways involved in mitochondrial metabolism and neurogenesis. We identify a subset of differentially expressed proteins that are supported by ASD transcriptomic and DNA methylation data. Furthermore, these differentially expressed proteins are enriched for disease phenotype pathways associated with ASD aetiology. These proteins converge on protein–protein interaction networks that regulate cell proliferation and differentiation, metabolism, and inflammation, which demonstrates a link between canonical pathways, biological processes and the ASD phenotype. This review highlights how proteomics can uncover potential molecular mechanisms to explain a link between mitochondrial dysfunction and neurodevelopmental pathology. Full article
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