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Special Issue "DNA-Based Vaccines against Infectious Diseases and Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 133

Special Issue Editor

Special Issue Information

Dear Colleagues,

Vaccines are one of the most important medical interventions for the prevention of infectious diseases and cancers. Among the technologies available for vaccine development, Nucleic-acid-based vaccination is a promising alternative to conventional vaccines, as the coding sequences can be easily altered with little impact to downstream production. Although mRNA vaccines have been recognized as next-generation vaccines, the ultra-low temperature storage of mRNA, low physical stability, and short half-life limits their global availability. In contrast, DNA vaccines are very stable, easy to manufacture, and non-HLA specific. However, the potential of DNA vaccines has not been realized due to the poor cellular uptake of DNA in vivo, resulting in poor immunogenicity. Recent advances in DNA vaccines with improved plasmids, antigen presentation, and optimized prime-boost strategies have improved the efficacy of vaccines. Despite the improvement, there are no FDA-approved DNA vaccines for human use. To further develop DNA vaccines with improved functionality, interdisciplinary-focused research will be of great use. We can develop a DNA vaccine with optimized vaccine scheduling, enhancement of antigen stability, improved immunogenicity, manufactured nano-plasmids, and improved delivery systems.

We welcome the submission of original research articles, reviews, mini-reviews, perspective articles, opinion articles, and commentaries around the following topics, including, but not limited to:

  • Recent advances in DNA vaccine technologies.
  • Synthetic DNA vaccines and DNA-encoded monoclonal antibodies (DMAbs) to prevent infectious diseases and cancer. 
  • Controlling gene expression using plasmid engineering and gene circuits.
  • Enhancing the duration of immune response using molecular adjuvants.
  • Novel methods to stabilize antigens for the development of vaccines.

Dr. Praveen Kumar Neeli and Dr. Dafei Chai are the Topical Advisory Panel Members of IJMS, and are assisting Dr. Srinivasa Reddy Bonam in supervising this Special Issue.

You may choose our Joint Special Issue in SynBio.

Dr. Srinivasa Reddy Bonam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA vaccine
  • immune responses
  • infectious disease
  • plasmids
  • vaccine

Published Papers

This special issue is now open for submission.
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