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Special Issue "Purine Nucleotides Metabolism and Signaling in Human Diseases: Search for a Target for Novel Therapies 2023"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 218

Special Issue Editor

Section de Structures Biologiques, Pharmacologie et Enzymologie, CNRS/Unistra, CRBS, UR 3072, CEDEX, 67084 Strasbourg, France
Interests: cAMP; cGMP; cellular signaling; cyclic nucleotide phosphodiesterase (PDE); subcellular compartments; Kinases

Special Issue Information

Dear Colleagues,

Among purine nucleotides metabolism, the cyclic AMP (cAMP) discovered as  the “second messenger”, was first investigated as the main contributor of intracellular signaling, as explored by the 1971 Nobel Prize in Physiology or Medicine recipient Earl W. Sutherland, Jr. Later, research was conducted for cGMP by 1998 Nobel Prize recipients, Robert F. Furchgott, Louis J. Ignarro and Ferid Murad. Currently, the development of molecular biology allows us to investigate and classify the superfamily of cyclic nucleotide phosphodiesterases. They specifically control cyclic nucleotides levels at different cellular levels, hydrolyzing cyclic nucleotides in their respective nucleotide monophosphates, which can modulate cellular signaling cascade.

Our knowledge of intracellular signaling regulation drastically increased during the last fifty years opening the development of multiple signaling pathways, issued from purine nucleotides.

In the present Special Issue, it would be of interest to consider not only part of the specific molecular regulations of signaling, but to consider the whole signalosome, determining links inside the regulatory cascade and purine nucleotides mechanisms in normal and pathological states in humans, in order to develop new therapeutic approaches.

Prof. Dr. Claire Lugnier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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  • cAMP
  • cGMP
  • AMP
  • GMP
  • PKA
  • PKG
  • CREB
  • cyclic nucleotide phosphodiesterase (PDE1-PDE11)
  • AMPkinase
  • MAPkinase
  • mRNA

Published Papers

There is no accepted submissions to this special issue at this moment.
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