Special Issue "Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases 2.0"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 6099
Interests: lysosomal storage disorders; vesicular trafficking; endosomal sorting; lysosome biogenesis; mitochondrial diseases; autoimmune disorders
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Mitogen-activated protein (MAP) kinases are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological and pathologic cellular responses. This signalling operates via a hierarchical cascade involving MAP3K, MAP2K and MAPK enzymes. Most studies have focused on the MAPK family, extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK) and p38 MAPK. There is considerable variation in MAP kinase functions across different cell types that make it challenging to extrapolate, from in vitro studies, to the whole organism. There is substantial interest in therapeutic targeting of individual MAP kinase enzymes in diseases ranging from cancer to chronic organ fibrosis.
This Special Issue of the International Journal of Molecular Sciences will focus on “Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases”. We welcome contributions on the regulation of MAP kinase functions in terms of how the signalling cascade is activated by different stimuli, signal transduction via scaffolding proteins, and termination of signalling via phosphatase enzymes. In addition, we welcome contributions examining the role of MAP kinases in pathogenesis in human and experimental disease; including tissue damage and repair mechanisms.
Prof. Dr. Ritva Tikkanen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- MAP kinase
- p38 MAPK
- Disease pathogenesis
- Kinase inhibition
- Signal transduction