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Bone Biomaterials Research and 3D Spheroid Culture Systems in Osteogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1383

Special Issue Editor

Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea
Interests: osteogenesis; 3D; bone spheroids; pharmacological assessment; bone materials

Special Issue Information

Dear Colleagues,

Various methods for bone research have been suggested, and many studies have focused on the most suitable materials and research methods for living organisms. However, it is still difficult to create standardized data according to the experimental environment and materials. To overcome this, a Special Issue dedicated to the intersection of “Bone Biomaterials Research and 3D Spheroid Culture Systems in Osteogenesis”, is a field poised to revolutionize our understanding of bone tissue engineering. This thematic collection aims to provide a comprehensive platform for researchers to explore the intricate molecular mechanisms underpinning osteogenesis within the context of 3D spheroid culture systems.

The interaction of bone biomaterials and 3D spheroid culture techniques represents a groundbreaking approach, offering unique insights into the complex interplay between cells, biomaterials, and their microenvironment during bone regeneration. This Special Issue invites researchers to contribute your original work, spanning from material design and fabrication processes to in-depth investigations into the molecular mechanisms governing osteogenic differentiation within 3D spheroid cultures.

As we delve into the molecular intricacies of osteogenesis, contributors are encouraged to explore themes such as signaling pathways, gene expression profiles, and cell-cell interactions that influence the fate of osteoprogenitor cells in 3D culture systems. We anticipate that this Special Issue will serve as a catalyst for innovative research at the crossroads of bone biomaterials and 3D spheroid cultures, fostering collaboration and driving advancements in regenerative medicine.

Researchers from diverse backgrounds are invited to submit their cutting-edge contributions, fostering a vibrant exchange of ideas and accelerating the translation of discoveries into practical applications. Together, let us unravel the mysteries of bone biomaterials and 3D spheroid culture systems, paving the way for transformative developments in the realm of osteogenesis research.

Dr. Chawon Yun
Guest Editor

Manuscript Submission Information

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Keywords

  • osteogenic differentiation
  • 3D culture
  • bone regeneration
  • toxicological and pharmacological assessment
  • bone homeostasis
  • bone materials

Published Papers (1 paper)

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Review

22 pages, 767 KiB  
Review
Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research
by Chawon Yun, Sou Hyun Kim, Kyung Mok Kim, Min Hye Yang, Mi Ran Byun, Joung-Hee Kim, Doyoung Kwon, Huyen T. M. Pham, Hyo-Sop Kim, Jae-Ho Kim and Young-Suk Jung
Int. J. Mol. Sci. 2024, 25(5), 2512; https://doi.org/10.3390/ijms25052512 - 21 Feb 2024
Viewed by 1156
Abstract
Bone differentiation is crucial for skeletal development and maintenance. Its dysfunction can cause various pathological conditions such as rickets, osteoporosis, osteogenesis imperfecta, or Paget’s disease. Although traditional two-dimensional cell culture systems have contributed significantly to our understanding of bone biology, they fail to [...] Read more.
Bone differentiation is crucial for skeletal development and maintenance. Its dysfunction can cause various pathological conditions such as rickets, osteoporosis, osteogenesis imperfecta, or Paget’s disease. Although traditional two-dimensional cell culture systems have contributed significantly to our understanding of bone biology, they fail to replicate the intricate biotic environment of bone tissue. Three-dimensional (3D) spheroid cell cultures have gained widespread popularity for addressing bone defects. This review highlights the advantages of employing 3D culture systems to investigate bone differentiation. It highlights their capacity to mimic the complex in vivo environment and crucial cellular interactions pivotal to bone homeostasis. The exploration of 3D culture models in bone research offers enhanced physiological relevance, improved predictive capabilities, and reduced reliance on animal models, which have contributed to the advancement of safer and more effective strategies for drug development. Studies have highlighted the transformative potential of 3D culture systems for expanding our understanding of bone biology and developing targeted therapeutic interventions for bone-related disorders. This review explores how 3D culture systems have demonstrated promise in unraveling the intricate mechanisms governing bone homeostasis and responses to pharmacological agents. Full article
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