Mitochondria: A Novel Therapeutic Target in Neurodegeneration
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1927
Interests: Parkinson's disease; multiple system atrophy; dementia with Lewy bodies; alpha-synuclein; small ubiquitin-like modifier (SUMO); metallothionein; neuroinflammation; calcium; copper; autophagy
Special Issues, Collections and Topics in MDPI journals
Loss of neuronal function is a major hallmark of normal aging and aging-associated diseases, such as amyotrophic lateral sclerosis, Parkinson’s, Huntington’s, and Alzheimer’s Diseases, among others. Neurodegeneration can have multiple causes and manifestations, but mitochondrial dysfunction is often a common feature. Mitochondria regulate many aspects of cellular metabolism, including bioenergetics, biosynthetic pathways, calcium, and redox homeostasis. They are also involved in controlling cell survival. Thus, therapeutic strategies targeting mitochondria are promising for a wide range of conditions. Interesting processes underlying mitochondrial involvement in neurodegeneration include metabolic and redox remodeling, mitochondrial uptake of nuclear-encoded proteins, intracellular and intercellular mitochondrial dynamics, mitochondrial quality control, and interactions of pathological proteins, such as alpha-synuclein, with mitochondria. In this Special Issue, we aim to highlight mitochondrial involvement in neurodegeneration, from potential biomarkers to opportunities for intervention. Original articles, comprehensive reviews, and perspective articles are welcome.
Prof. Dr. Jiří Neužil
Dr. Dean L. Pountney
Dr. Teresa Cunha-Oliveira
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- mitochondrial profiling
- redox homeostasis
- clinical biomarkers
- mitochondrial therapy