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Skeletal Muscle Metabolism—Effects of Diet, Exercise and Pharmacotherapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 182

Special Issue Editor

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Guest Editor
Department of Nutrition, Exercise and Sports, University of Copenhagen, DK-2200 Copenhagen, Denmark
Interests: exercise; physical activity; skeletal muscle; energy metabolism; cellular signaling; metabolic disorders; tissue-specific drug targeting; drug discovery
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Special Issue Information

Dear Colleagues,

Skeletal muscle is not only essential for movement and posture, but it also plays a vital role in regulating whole-body metabolism. Accounting for ~40% of body mass, skeletal muscle is the primary site of insulin-mediated glucose disposal and a major contributor to resting energy expenditure. As such, any alterations in skeletal muscle function or metabolism can have profound implications for the development and progression of metabolic disorders.

Skeletal muscle is also a highly dynamic organ, capable of increasing energy turnover by more than 100-fold during exercise. This remarkable metabolic plasticity is underpinned by a complex network of intracellular signaling pathways that are responsive to a wide range of factors, including diet and exercise.

In recent years, skeletal muscle has also emerged as a major endocrine organ, releasing myokines that act on distant tissues to regulate metabolism, inflammation, and immunity. This role of skeletal muscle as an endocrine organ further underscores its critical importance for overall health and well-being.

The current Special Issue of the International Journal of Molecular Sciences is dedicated to exploring the latest advances in our understanding of skeletal muscle metabolism and its regulation by diet, exercise, and pharmacotherapies. The Special Issue features a collection of original research articles and review papers that highlight the complex interplay between these factors in shaping skeletal muscle function and metabolism in health and disease.

Specifically, the Special Issue covers a broad range of topics, including:

  • The molecular mechanisms by which diet, exercise, and pharmacotherapies regulate skeletal muscle metabolism;
  • The role of skeletal muscle metabolism in metabolic disorders such as obesity, type 2 diabetes, and sarcopenia;
  • The emerging role of skeletal muscle as an endocrine organ and the implications of myokines for health and disease;
  • The development of novel therapeutic strategies targeting skeletal muscle metabolism for the treatment of metabolic disorders.

I hope that this Special Issue will provide a valuable resource for researchers and clinicians interested in the field of skeletal muscle metabolism.

Dr. Rasmus Kjøbsted
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • energy metabolism
  • metabolic signaling pathways
  • metabolic homeostasis
  • metabolic disorders
  • muscle mass
  • muscle metabolites
  • diet
  • exercise
  • pharmacotherapies

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Published Papers

This special issue is now open for submission.
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