Journal Browser

► Journal Browser

Special Issue "Novel Hypotheses for Alzheimer's Disease"

Share This Special Issue

Special Issue Editors

Special Issue Information

Dear Colleagues,

Although Alzheimer's disease (AD) is an international public health problem, affecting over 50 million people, there are only very limited disease-modifying treatments. Our understanding of the events that trigger the degenerative process and facilitate its relentless progression are limited because of the gradual onset of subtle cognitive changes and the difficulty in distinguishing AD from other conditions. Although tau and amyloid pathologies are present in the later stages of the disease, it is not clear that they represent the original pathophysiologic causes.

This Special Issue will focus on novel hypotheses regarding the cause, progression, or treatment of AD. These could be in the form of reinterpreting existing data or new data from demographic, imaging, molecular, or neurophysiologic studies with a translational component. Research using big datasets that encompass demographic, behavioral, radiologic, biochemical, molecular, or electrophysiologic data are of extreme interest, but any approach will be considered.

This Special Issue can be a means of bringing together scholars from different backgrounds to contribute to this important topic.

Dr. Mark M. Stecker
Dr. Allison B. Reiss
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Alzheimer's disease
cause of AD
treatment of AD
progression of AD
big data

Published Papers (2 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Open AccessArticle

Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons

Kazue Hashimoto-Torii

Dedra Buchwald

and

Robert J. Freishtat

Int. J. Mol. Sci. 2023, 24(18), 14024; https://doi.org/10.3390/ijms241814024 - 13 Sep 2023

Viewed by 720

Abstract

Alzheimer disease (AD) is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, synaptic dysfunction, and progressive dementia. Midlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have been implicated as a mechanism in several obesity-related diseases. We hypothesized that ad-sEVs from patients with AD would contain miRNAs predicted to downregulate pathways involved in synaptic plasticity and memory formation. We isolated ad-sEVs from the serum and cerebrospinal fluid (CSF) of patients with AD and controls and compared miRNA expression profiles. We performed weighted gene co-expression network analysis (WGCNA) on differentially expressed miRNAs to identify highly interconnected clusters correlating with clinical traits. The WGCNA identified a module of differentially expressed miRNAs, in both the serum and CSF, that was inversely correlated with the Mini-Mental State Examination scores. Within this module, miRNAs that downregulate CREB signaling in neurons were highly represented. These results demonstrate that miRNAs carried by ad-sEVs in patients with AD may downregulate CREB signaling and provide a potential mechanistic link between midlife obesity and increased risk of AD. Full article

(This article belongs to the Special Issue Novel Hypotheses for Alzheimer's Disease)

► Show Figures

Figure 1

Open AccessArticle

The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer’s Disease Reveals New Insights for AD Study

Lory J. Rochín-Hernández

Miguel A. Jiménez-Acosta

Lorena Ramírez-Reyes

María del Pilar Figueroa-Corona

Víctor J. Sánchez-González

Maribel Orozco-Barajas

and

Marco A. Meraz-Ríos

Int. J. Mol. Sci. 2023, 24(16), 12606; https://doi.org/10.3390/ijms241612606 - 09 Aug 2023

Viewed by 824

Abstract

Alzheimer’s disease (AD), the most common neurodegenerative disease and the first cause of dementia worldwide, has no effective treatment, and its pathological mechanisms are not yet fully understood. We conducted this study to explore the proteomic differences associated with Familial Alzheimer’s Disease (FAD) in olfactory ecto-mesenchymal stem cells (MSCs) derived from PSEN1 (A431E) mutation carriers compared with healthy donors paired by age and gender through two label-free liquid chromatography-mass spectrometry approaches. The first analysis compared carrier 1 (patient with symptoms, P1) and its control (healthy donor, C1), and the second compared carrier 2 (patient with pre-symptoms, P2) with its respective control cells (C2) to evaluate whether the protein alterations presented in the symptomatic carrier were also present in the pre-symptom stages. Finally, we analyzed the differentially expressed proteins (DEPs) for biological and functional enrichment. These proteins showed impaired expression in a stage-dependent manner and are involved in energy metabolism, vesicle transport, actin cytoskeleton, cell proliferation, and proteostasis pathways, in line with previous AD reports. Our study is the first to conduct a proteomic analysis of MSCs from the Jalisco FAD patients in two stages of the disease (symptomatic and presymptomatic), showing these cells as a new and excellent in vitro model for future AD studies. Full article

(This article belongs to the Special Issue Novel Hypotheses for Alzheimer's Disease)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Novel Hypotheses for Alzheimer's Disease"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (2 papers)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI