Special Issue "Infection and the Kidney"
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 27118
Interests: rapidly progressive glomerulonephritis; ANCA-associated vasculitis; infection-related glomerulonephritis; post-infectious acute glomerulonephritis; renal interstitial fibrosis; renal transplantation–recurrence of glomerulonephritis; renal transplantation-infection-related complications; role of complements in renal disease; chronic kidney disease; kidney diseases caused by viral infection; kidney diseases caused by bacterial infection
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Infection is known to induce kidney parenchymal injury directly or indirectly through various mechanisms in various renal diseases. For example, severe bacterial infection can cause sepsis that may involve the kidneys in the form of acute kidney injury (AKI), which is a life-threatening condition. It has also been recently revealed that severe infection with COVID-19 can frequently lead to the development of AKI. Direct infection with a virus (such as BK virus) in the parenchyma of the kidneys leads to tubulo-interstitial nephritis, which is a common, kidney-threatening condition in transplanted kidneys. On the other hand, certain infections (bacterial or viral, focal or systemic) can indirectly relate to the development of various renal diseases, such as infection-related glomerulonephritis (IRGN), IgA-dominant IRGN, IgA nephropathy, IgA vasculitis, ANCA-associated glomerulonephritis, and thrombotic microangiopathy (TMA), through various mechanisms, such as nephritogenic bacterial protein with related plasmin activity, bacterial toxin with super-antigenic property, formation of autoantibodies (ANCA, ANA, anti-DNA antibody, antibodies to complement components, etc.), bacterial neuraminidase exposing hidden antigens to naturally existing autoantibodies, and so on.
A detailed understanding of the mechanisms of the relationship between infection and the kidneys is important because it may also lead to the elucidation of the pathogenic mechanism of idiopathic renal diseases. This Special Issue, “Infection and the Kidneys”, welcomes original research and review articles in the field, with a focus on but not limited to kidney injury directly or indirectly related with infection, such as sepsis-associated AKI, AKI in COVID-19, IRGN, IgA-IRGN, IgA nephropathy, IgA vasculitis, infection-induced ANCA-associated glomerulonephritis, infection-associated TMA, and direct viral infection on transplanted kidney.
Prof. Dr. Takashi Oda
Manuscript Submission Information
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sepsis-associated acute kidney injury (AKI)
infection-related glomerulonephritis (IRGN)
viral infection on transplanted kidneys