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Biomaterials and Tissue Regeneration in Craniofacial Defect Reconstruction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 93

Special Issue Editors

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Guest Editor
1. Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Titu Maiorescu University, 031593 Bucharest, Romania
2. Department of Oral and Maxillofacial Surgery, Carol Davila Central Military Emergency Hospital, 010825 Bucharest, Romania
Interests: tissue regeneration; healing; head and neck cancer; biomaterials; inflammation; biomarkers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. European Centre of Oral Implantology, 011473 Bucharest, Romania
2. Oral Implantology Department, Faculty of Dental Medicine, Titu Maiorescu University, 031593 Bucharest, Romania
Interests: implantology; oral rehabilitation; biomaterials

Special Issue Information

Dear Colleagues,

Craniofacial defects can arise from various causes, including congenital anomalies, trauma, tumor resection, and surgical interventions. Reconstruction in the craniofacial region presents unique challenges due to the complex anatomy and the need to restore both functional and aesthetic aspects. Successful craniofacial defect reconstruction often requires a multidisciplinary approach to ensure comprehensive evaluation and customized treatment planning to address individual patient needs. Biomaterials play a crucial role in craniofacial defect reconstruction, serving as scaffolds for tissue regeneration or as implants to restore structural integrity. Tissue engineering approaches involving stem cells, growth factors, and bioactive scaffolds hold promise for enhancing tissue regeneration and improving long-term outcomes. These constructs elicit a complex biological response upon implantation. Various tangled signaling mechanisms orchestrate cellular activities essential for tissue repair and regeneration. Different types of cells interact with biomaterials to influence the healing process. Surface properties, such as topography and chemistry, modulate cell adhesion, proliferation, and differentiation. Understanding these molecular mechanisms enables tailoring specific regenerative applications in craniofacial defect reconstruction.

In this Special Issue, we invite contributions that shed light on the molecular mechanisms involved in the successful reconstruction of craniofacial defects. We encourage researchers to submit manuscripts presenting original research findings, review papers, innovative methodologies, and conceptual advances in this field. We aim to investigate and deepen the understanding of the molecular features defining the perfect craniofacial reconstruction model.

Prof. Dr. Ana Caruntu
Prof. Dr. Horia Barbu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • biomaterials
  • biocompatibility
  • tissue engineering
  • craniofacial defect
  • oral rehabilitation
  • scaffolds
  • regenerative medicine
  • angiogenesis
  • stem cells

Published Papers

This special issue is now open for submission.
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