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Molecular Applications of Gold Nanoparticles in Cancer Theranostics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 99

Special Issue Editors

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Guest Editor
Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Interests: therapy medical physics; MRI-guided RT; quantitative imaging; cancer radiomics; pre-clinical image-guided RT; nanoparticles assisted radiotherapy
1. Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
2. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Interests: prostate cancer treatment; nanotechnology; targeted treatment; radiosensitization; drug delivery; nanoparticles
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Special Issue Information

Dear Colleagues,

Nanoparticles have emerged as promising tools in the field of medicine, particularly in the realm of cancer research, offering opportunities for early detection, precise diagnosis, and tailored treatment strategies. Among these nanoparticles, gold nanoparticles (AuNPs) have garnered significant attention due to their unique attributes. These include their high density and atomic number, excellent biocompatibility with minimal toxicity, stability, low osmolality and viscosity, and efficient uptake by mammalian cells through endocytosis. The exceptional properties of AuNPs have paved the way for their diverse applications in cancer treatment modalities such as photothermal therapy, photodynamic therapy, sonodynamic therapy, and radiation therapy. Furthermore, the inherent physical characteristics of AuNPs make them well-suited for various cancer imaging techniques, including CT, optical imaging, Raman spectroscopy imaging, photoacoustic imaging, X-ray fluorescence imaging, and X-ray acoustic imaging. Additionally, their ease of synthesis and surface functionalization contribute to their wide range of molecular applications, for instance, but not limited to:

  • AuNPs can be conjugated with ferro- or para-magnetic probes or radioisotopic probes to enhance the sensitivity of cancer diagnosis through MRI or PET/SPECT imaging.
  • AuNPs have been functionalized with targeting ligands to selectively deliver chemotherapeutic drugs to cancer cells while minimizing systemic toxicity.
  • AuNPs have been utilized to deliver immunomodulatory agents, such as cytokines or immune checkpoint inhibitors, to modulate the tumor microenvironment and enhance anti-tumor immune responses. By targeting immune cells or tumor-associated antigens, AuNPs can regulate immune cell function and promote anti-cancer immune responses.
  • AuNPs have demonstrated efficacy in delivering nucleic acids, including aptamers and small interfering RNA (siRNA), for targeted gene therapy applications.

This versatility underscores the potential of AuNPs as multifunctional nanoplatforms in cancer theranostics. This Special Issue of the International Journal of Molecular Sciences (IJMS) aims to offer a comprehensive overview of advancements in AuNP-based molecular applications in cancer theranostics by assembling contributions from researchers around the world.

Dr. John Chetley Ford
Dr. Junwei Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gold nanoparticles (AuNPs)
  • multifunctional nanoplatform
  • targeted cancer therapy
  • drug delivery
  • theranostics

Published Papers

This special issue is now open for submission.
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