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Special Issue "Application of Nanostructures in Biology and Medicine"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 December 2023 | Viewed by 4140

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Special Issue Editor

Dr. Kirill A. Lozovoy

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Guest Editor

Faculty of Radiophysics, Tomsk State University, Tomsk 634050, Russia
Interests: nanoscience; 2D materials; quantum dots; epitaxy; photoluminescence; nanophotonics; photodetectors; light-emitting devices; quantum information technology; single-photon detectors; molecular dynamics; functional electronics

Special Issue Information

Dear Colleagues,

At present, nanomaterials are used in a wide range of applications, in all spheres of civil needs, including energy, medicine and industry. Moreover, they are considered one of the most promising classes of materials for the next generation of technological development. The interest in the possibilities of application of nanoparticles and nanodevices allows a deeper study of the physical properties of these new materials, and provides a starting point for the development of a huge number of practically important areas, starting from synthetic biology, drug delivery platforms and brain–computer interfaces to nanoelectronics, nanophotonics and quantum communications technologies.

This Special Issue focuses on recent research in all fields of applied nanoscience, including but not limited to materials science, molecular and cell biology, genetics, and biotechnology. Special attention will be paid to the state-of-the-art methods of the synthesis and characterization of advanced materials, nanoparticles and biological objects. Computer-based theoretical modeling of nano-objects and their emerging applications is also welcomed.

Since IJMS is a journal of molecular science, pure clinical studies will not suitable for the journal; however, clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Kirill A. Lozovoy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

materials science
synthetic biology
biotechnology
cell biology
metagenomics
bioimaging
nanostructures
nanodevices
green nanotechnology

Published Papers (3 papers)

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17 pages, 2052 KiB

Open AccessArticle

Application of Iron Nanoparticles Synthesized from a Bioflocculant Produced by Yeast Strain Pichia kudriavzevii Obtained from Kombucha Tea SCOBY in the Treatment of Wastewater

Phakamani H. Tsilo

Albertus K. Basson

Zuzingcebo G. Ntombela

Nkosinathi G. Dlamini

and

Rajasekhar V. S. R. Pullabhotla

Int. J. Mol. Sci. 2023, 24(19), 14731; https://doi.org/10.3390/ijms241914731 - 29 Sep 2023

Viewed by 677

Abstract

Studying the production of Iron (Fe) nanoparticles using natural substances is an intriguing area of research in nanotechnology, as these nanoparticles possess biocompatibility and natural stability, which make them useful for a variety of industrial applications. The study utilized Fe nanoparticles that were synthesized using a bioflocculant and applied to eliminate different kinds of pollutants and dyes found in wastewater and solutions. The study involved the generation of Fe nanoparticles through a bioflocculant obtained from Pichia kudriavzevii, which were evaluated for their flocculation and antimicrobial capabilities. The impact of the Fe nanoparticles on human embryonic kidney (HEK 293) cell lines was studied to assess their potential cytotoxicity effects. An array of spectroscopic and microscopic methods was employed to characterize the biosynthesized Fe nanoparticles, including SEM-EDX, FT-IR, TEM, XRD, UV-vis, and TGA. A highly efficient flocculating activity of 85% was achieved with 0.6 mg/mL dosage of Fe nanoparticles. The biosynthesized Fe nanoparticles demonstrated a noteworthy concentration-dependent cytotoxicity effect on HEK 293 cell lines with the highest concentration used resulting in 34% cell survival. The Fe nanoparticles exhibited strong antimicrobial properties against a variety of evaluated Gram-positive and Gram-negative microorganisms. The efficiency of removing dyes by the nanoparticles was found to be higher than 65% for the tested dyes, with the highest being 93% for safranine. The Fe nanoparticles demonstrated remarkable efficiency in removing various pollutants from wastewater. In comparison to traditional flocculants and the bioflocculant, biosynthesized Fe nanoparticles possess significant potential for eliminating both biological oxygen demand (BOD) and chemical oxygen demand (COD) from wastewater samples treated. Hence, the Fe nanoparticles synthesized in this way have the potential to substitute chemical flocculants in the treatment of wastewater. Full article

(This article belongs to the Special Issue Application of Nanostructures in Biology and Medicine)

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25 pages, 2764 KiB

Open AccessReview

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Rita Y. P. da Silva

Danielle L. B. de Menezes

Verônica da S. Oliveira

Attilio Converti

and

Ádley A. N. de Lima

Int. J. Mol. Sci. 2023, 24(6), 5441; https://doi.org/10.3390/ijms24065441 - 13 Mar 2023

Cited by 2 | Viewed by 1583

Abstract

Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1–1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field. Full article

(This article belongs to the Special Issue Application of Nanostructures in Biology and Medicine)

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20 pages, 1241 KiB

Open AccessReview

Management and Mitigation of Vibriosis in Aquaculture: Nanoparticles as Promising Alternatives

Nuan Anong Densaad Kah Sem

and

Int. J. Mol. Sci. 2023, 24(16), 12542; https://doi.org/10.3390/ijms241612542 - 08 Aug 2023

Viewed by 1450

Abstract

Vibriosis is one of the most common diseases in marine aquaculture, caused by bacteria belonging to the genus Vibrio, that has been affecting many species of economically significant aquatic organisms around the world. The prevention of vibriosis in aquaculture is difficult, and the various treatments for vibriosis have their limitations. Therefore, there is an imperative need to find new alternatives. This review is based on the studies on vibriosis, specifically on the various treatments and their limitations, as well as the application of nanoparticles in aquaculture. One of the promising nanoparticles is graphene oxide (GO), which has been used in various applications, particularly in biological applications such as biosensors, drug delivery, and potential treatment for infectious diseases. GO has been shown to have anti-bacterial properties against both Gram-positive and Gram-negative bacteria, but no research has been published that emphasizes its impact on Vibrio spp. The review aims to explore the potential use of GO for treatment against vibriosis. Full article

(This article belongs to the Special Issue Application of Nanostructures in Biology and Medicine)

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Special Issue "Application of Nanostructures in Biology and Medicine"

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