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Special Issue "New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 1212

Special Issue Editor

1. Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia
2. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia
Interests: silver nanoparticles; antimicrobial conjugates; physical and chemical methods to increase activity; cytotoxicity

Special Issue Information

Dear Colleagues,

Antimicrobial properties are key parameters for the practical application of some nanoparticles. Infections and drug resistance remain key challenges in the 21st century and developing methods to fight them is an important task in modern science. Antimicrobial nanoparticles even have advantages over antibiotics, especially when applied topically. Antimicrobial nanoparticles can be used both in the creation of new pharmaceuticals and in the production of new materials, devices, tools, household items, and even clothing, due to their anti-infective properties against a wide range of microorganisms, including bacteria, protozoa, fungi, and viruses. The development of technologies for the creation, study, and effective use of antimicrobial nanoparticles, as well as the expansion of areas and methods for their use, significantly contribute to the fight against infection and drug resistance. This Special Issue, supervised by Dr. Evgenii Plotnikov (Tomsk Polytechnic University, Russia) and assisted by Dr. Anton Artamonov (Russian Academy of Sciences, Russia), aims to summarize and update achievements in this field, and author submissions will enable us to achieve this goal.

Dr. Evgenii Plotnikov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial nanoparticles
  • alternative to antibiotics
  • physical and chemical activation of nanoparticles
  • multi-drug resistance
  • mechanisms of anti-infective action

Published Papers (1 paper)

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17 pages, 3924 KiB  
Revealing the Second and the Third Causes of AgNPs Property to Restore the Bacterial Susceptibility to Antibiotics
Int. J. Mol. Sci. 2023, 24(9), 7854; https://doi.org/10.3390/ijms24097854 - 26 Apr 2023
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The increase in bacterial resistance to antibiotics is a global problem for public health. In our previous works, it was shown that the application of AgNPs in cow mastitis treatment increased S. aureus and S. dysgalactiae susceptibility to 31 antibiotics due to [...] Read more.
The increase in bacterial resistance to antibiotics is a global problem for public health. In our previous works, it was shown that the application of AgNPs in cow mastitis treatment increased S. aureus and S. dysgalactiae susceptibility to 31 antibiotics due to a decrease in the bacterial efflux effect. The aim of the present work was to shed light on whether the change in adhesive and anti-lysozyme activities caused by AgNPs also contribute to the restoration of bacterial susceptibility to antibiotics. In vivo sampling was performed before and after cow mastitis treatments with antibiotics or AgNPs. The isolates were identified, and the adhesive and anti-lysozyme activities were assessed. These data were compared with the results obtained for in vitro pre-treatment of reference bacteria with AgNPs or antibiotics. The present study revealed that bacterial treatments in vitro and in vivo with AgNPs: (1) decrease the bacterial ability to adhere to cells to start an infection and (2) decrease bacterial anti-lysozyme activity, thereby enhancing the activity of lysozyme, a natural “antibiotic” present in living organisms. The obtained data contribute to the perspective of the future application of AgNPs for recovering the activity of antibiotics rapidly disappearing from the market. Full article
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