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Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 207

Special Issue Editor


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Special Issue Information

Dear Colleagues,

Ligaments, tendons and cartilage share many tissue characteristics, such as the following: a poor or absent blood supply, a low cell content, and an abundant collagenous extracellular matrix. Some of these properties may explain their limited self-healing capacity during tissue injury.

Hence, tissue engineering (TE) represents a promising strategy for tissue reconstruction. Using novel biomimetic biomaterials as chondro-/tenogenic cell carriers represents an innovative culturing approach; e.g., using smart bioreactors and versatile bioprinting strategies could support the regeneration of these tissues with tissue engineered implants. Cells recruited for TE, the tailored release of bioactive factors, and targeted cell lineage differentiation are also of interest. Novel data describing in vivo TE results gained using animal models are also welcome.

Lead by Prof. Dr. Gundula Schulze-Tanzil and assisted by our Topical Advisory Panel Member, Dr. Clemens Gögele (Paracelsus Medical University), this Special Issue will focus on the most recent developments in tendon/ligament and cartilage tissue engineering, comprising in vitro and in vivo studies.

Prof. Dr. Gundula Schulze-Tanzil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • cartilage
  • tendon
  • ligament
  • anterior cruciate ligament
  • bioprinting
  • scaffold
  • bioreactor
  • tissue engineering

Published Papers (1 paper)

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Review

23 pages, 3213 KiB  
Review
A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue
by Viviana Reyes Alcaraz, Girish Pattappa, Shigenori Miura, Peter Angele, Torsten Blunk, Maximilian Rudert, Yuji Hiraki, Chisa Shukunami and Denitsa Docheva
Int. J. Mol. Sci. 2024, 25(11), 5839; https://doi.org/10.3390/ijms25115839 (registering DOI) - 27 May 2024
Abstract
Articular cartilage is crucial for joint function but its avascularity limits intrinsic repair, leading to conditions like osteoarthritis (OA). Chondromodulin-I (Cnmd) has emerged as a key molecule in cartilage biology, with potential implications for OA therapy. Cnmd is primarily expressed in cartilage and [...] Read more.
Articular cartilage is crucial for joint function but its avascularity limits intrinsic repair, leading to conditions like osteoarthritis (OA). Chondromodulin-I (Cnmd) has emerged as a key molecule in cartilage biology, with potential implications for OA therapy. Cnmd is primarily expressed in cartilage and plays an important role in chondrocyte proliferation, cartilage homeostasis, and the blocking of angiogenesis. In vivo and in vitro studies on Cnmd, also suggest an involvement in bone repair and in delaying OA progression. Its downregulation correlates with OA severity, indicating its potential as a therapeutic target. Further research is needed to fully understand the mode of action of Cnmd and its beneficial implications for managing OA. This comprehensive review aims to elucidate the molecular characteristics of Cnmd, from its expression pattern, role in cartilage maintenance, callus formation during bone repair and association with OA. Full article
(This article belongs to the Special Issue Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction)
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