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Molecular Genetics in Neurodegenerative Disorders 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 3005

Special Issue Editors


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Guest Editor
Cellular Models and Neuroepigenetics Unit-IRCCS Mondino Foundation, 27100 Pavia, Italy
Interests: ALS; biomarker discovery; iPSCs; protein misfolding; extracellular vesicles; RNA metabolism
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Cellular Models and Neuroepigenetics Unit-IRCCS Mondino Foundation, 27100 Pavia, Italy
Interests: neurodegenerative disorders; genetics; epigenetics; biomarker discovery; genome instability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurodegenerative disorders (NDs) are characterized by the progressive and inevitable loss of selected neuronal populations in the peripheral or central nervous system, which leads to impairments in motor, behavioral and/or cognitive function. NDs mainly include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS). Previous studies have indicated that NDs are caused by multiple pathomechanisms, although each ND has different clinical characteristics, neuropathological targets and losses of selected neuronal populations. Among the pathomechanisms underlying NDs are genetic mutations, micro- and long-RNA (miRNA and lnRNA) network alterations, glutamate excitotoxicity, redox imbalance, neuroinflammation, mitochondria dysfunction, endoplasmic reticulum stress, autophagy dysfunction and, more recently, epigenetics. However, the exact causes of most NDs are still unknown, and recent studies suggest that therapeutic options in ND management remain limited.

With this Special Issue, we intend to collect both original contributions and review articles focused on recent advances in: i) genetic research on new gene-specific therapeutic approaches in treating ND patients; ii) the investigation of the mechanisms of epigenetic regulation (DNA methylation, coding and non-coding RNA, chromatin remodeling and histone post-translational modifications); iii) the identification of biomarkers able to predict disease progression; iv) the understanding of specific molecular mechanisms, including DNA damage repair, genome instability and RNA metabolism.

Dr. Orietta Pansarasa
Dr. Matteo Bordoni
Guest Editors

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Published Papers (1 paper)

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Review

41 pages, 2038 KiB  
Review
Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis
by Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia-Petre Costin, Luca-Andrei Glavan, Antonio-Daniel Corlatescu and Vicentiu Mircea Saceleanu
Int. J. Mol. Sci. 2023, 24(13), 10809; https://doi.org/10.3390/ijms241310809 - 28 Jun 2023
Cited by 9 | Viewed by 2432
Abstract
Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, [...] Read more.
Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We intend through this review to focus on the newest treatment, diagnosis, and predictions regarding this large group of diseases, in order to obtain a more accurate analysis and to identify the emerging signs that could lead to a better outcome in order to increase both the quality and the life span of the patient. Moreover, this review could provide evidence of future possible novel therapies that target the specific genes and that could be useful to be taken into consideration when the classical approaches fail to shed light. Full article
(This article belongs to the Special Issue Molecular Genetics in Neurodegenerative Disorders 2.0)
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