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Special Issue "New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 15 March 2024 | Viewed by 1072

Special Issue Editors

A.N. Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia
Interests: nanoparticles; nanoparticle–bioreceptor conjugates; nanozymes; biosensors; immunoassay; isothermal amplification; recombinase polymerase amplification; loop-mediated amplification; CRISPR/Cas; amplification approaches for biosensors
Dr. Yi Wan
E-Mail Website
Guest Editor
State Key Laboratory of Marine Resource Utilization in South China Sea, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
Interests: biosensors; microbiological diagnostic mechanisms
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Special Issue Information

Dear Colleagues,

Combining nanoparticles and biomolecules into hybrid structures (conjugates) provides powerful tools for managing delivery, recognition, and detection processes, applicable both in vitro and in vivo. Updating in research and gaining new knowledge about nanoparticles as a career for bioreceptor molecules is necessary due to significant progress in the synthesis of new types of nanoparticles, the extension of used bioreceptor molecules, and innovative tools for high-throughput studies at a molecular level. Accordingly, the priority focus of our special issue is new nanoparticles, biomolecules, and approaches for their characterization.

In this Special Issue, we will consider the progress towards

  • obtaining nanoparticles used as carriers for bioreceptor molecules;
  • characterization and improving the properties of conjugates of nanoparticles with antibodies, aptamers, nucleic acids, enzymes, and other biomolecules;
  • theoretical and experimental studies of composition - property correlations for the nanoparticle–bioreceptor conjugates;
  • application of the nanoparticle–bioreceptor conjugates in diagnostics, delivery, and therapy.

This Special Issue aims at expanding the knowledge on obtaining, characterization, and applications for nanoparticles–bioreceptor conjugates. Experimental studies in biochemistry, molecular biology, biotechnology, and biomedicine, review articles, and clinical studies are all welcome for consideration.

Dr. Irina Safenkova
Dr. Yi Wan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanoparticles
  • nanozymes
  • fluorescent nanoparticles
  • aggregates of nanoparticles
  • antibody
  • aptamer
  • nanoparticle–bioreceptor conjugates
  • protein corona
  • nanoparticle-based biosensors
  • enhanced immunoassays
  • isothermal amplification
  • nanoparticle-based therapy
  • nanoparticle-based delivery
  • nanotheranostics

Published Papers (1 paper)

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29 pages, 4493 KiB  
CRISPR/Cas-Based Techniques for Live-Cell Imaging and Bioanalysis
Int. J. Mol. Sci. 2023, 24(17), 13447; https://doi.org/10.3390/ijms241713447 - 30 Aug 2023
Viewed by 853
CRISPR/Cas systems have found widespread applications in gene editing due to their high accuracy, high programmability, ease of use, and affordability. Benefiting from the cleavage properties (trans- or cis-) of Cas enzymes, the scope of CRISPR/Cas systems has expanded beyond gene [...] Read more.
CRISPR/Cas systems have found widespread applications in gene editing due to their high accuracy, high programmability, ease of use, and affordability. Benefiting from the cleavage properties (trans- or cis-) of Cas enzymes, the scope of CRISPR/Cas systems has expanded beyond gene editing and they have been utilized in various fields, particularly in live-cell imaging and bioanalysis. In this review, we summarize some fundamental working mechanisms and concepts of the CRISPR/Cas systems, describe the recent advances and design principles of CRISPR/Cas mediated techniques employed in live-cell imaging and bioanalysis, highlight the main applications in the imaging and biosensing of a wide range of molecular targets, and discuss the challenges and prospects of CRISPR/Cas systems in live-cell imaging and biosensing. By illustrating the imaging and bio-sensing processes, we hope this review will guide the best use of the CRISPR/Cas in imaging and quantifying biological and clinical elements and inspire new ideas for better tool design in live-cell imaging and bioanalysis. Full article
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