Special Issue "The Role of Estrogen and Its Receptors in the Development and Therapy of Cancer"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 5696
Interests: mitochondria; breast cancer; oxidative stress; inflammation; metastasis
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Estrogens are steroid hormones that exert a wide variety of effects on the growth, development, and differentiation of different tissues. However, they also affect the oncogenic process and have a key role in several hormone-dependent cancers, such as breast and ovarian cancer. The action of estrogens is mediated through its binding to estrogen receptors (ER). Three different subtypes of ER have been described: ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). These receptors can either trigger a genomic response through the modulation of gene transcription or non-genomic effects through the modulation of several protein kinases. The molecular mechanisms underlying the role of ER remain to be elucidated. For instance, ERα has been associated with increased tumor cell proliferation, while ERβ seems to induce apoptosis and cell differentiation. Thus, the ratio between these two receptors becomes crucial to determine the effects of estrogens in cancer cells. Furthermore, GPER1 has been associated with the maintenance of cancer stem cells and resistance to anticancer therapies.
This Special Issue aims to gain insight into the roles of estrogens and estrogen receptors in different types of cancer, tumor development, progression, and metastasis. We welcome original research papers and reviews covering, but not limited to the following research questions:
- Molecular mechanisms of estrogen–ER signaling and function in cancer cells;
- Mechanisms of resistance to anticancer therapy modulated by estrogens and ER;
- Modulation of ER expression and its influence on tumor progression.
Dr. Margalida Torrens-Mas
Dr. Mercedes Nadal-Serrano
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- estrogen receptor
- breast cancer
- anticancer therapy
- cancer development
- cancer progression