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Redox Physiology in Biomedicine and Ecophysiology: The Influence of Various Substances on the Redox Regulation of Cell Metabolism, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 934

Special Issue Editor

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Guest Editor
Institute for Biological Research “Siniša Stanković”-National Institute of the Republic of Serbia, Belgrade, Serbia
Interests: redox physiology; antioxidative defense system; animal and human physiology; general and biomedical ecophysiology; metallomics; pathophysiology; toxicology
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in a Special Issue of MDPI’s International Journal of Molecular Sciences (ISSN 1422-0067) entitled: “Redox Physiology in Biomedicine and Ecophysology: Influence of Various Substances in Redox Regulation of Cell Metabolism 2.0”. It became clear that the modulation of the redox status can be the cause of many pathophysiological conditions in animals and humans. This is why this Special Issue covers a wide range of biomedical research with a special emphasis on results at the molecular level. We encourage authors to submit their manuscripts relating to: the impact of redox-active pollutants on the reproductive health of women and men; the connection between redox regulation of cellular redox status in COVID-19/post-COVID-19 patients; reactive species in redox signaling; redox-active natural products in diabetes; toxic trace elements in placental tissue, umbilical cord, and maternal blood in pregnant women with physiological pregnancies; influence of various xenobiotics on cellular redox status in aquatic organisms; and the influence of redox-active trace metals in physiological processes in normal and pathophysiological conditions.

Both Original research papers and Review articles are welcome.

Dr. Sladjan Z. Pavlović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • redox-signalling pathways
  • antioxidative and hypoglicemic effects of plant extracts
  • prooxidant/antioxidant status in the cells
  • redox active trace metals
  • reproductive health of women and men: infertility/sterility
  • xenobiotics in aquatic organims
  • essential trace elements and immunological parameters in COVID/post-COVID patients

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Published Papers (1 paper)

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14 pages, 6006 KiB  
Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis
by Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin and Hongbo Hu
Int. J. Mol. Sci. 2024, 25(5), 2458; https://doi.org/10.3390/ijms25052458 - 20 Feb 2024
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Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative [...] Read more.
Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat AKI. Glycyrol (GC) is a representative coumarin compound isolated from licorice that demonstrates various pharmacological activities. However, its potential for a protective effect against kidney injury remains unknown. We hypothesized that GC might be able to protect against AKI via suppression of ferroptosis. This hypothesis was tested in a cell-culture model of RSL3-induced nephrocyte ferroptosis and a mouse model of folic acid-induced AKI. The results showed that GC exerted a significant protective effect against nephrocyte ferroptosis in vitro and was effective against folic acid-induced AKI in vivo, where it was mechanistically associated with suppressing HO-1-mediated heme degradation. Collectively, the findings of the present study support the hypothesis that GC holds considerable potential to be developed as a novel agent for treating ferroptosis-related AKI. Full article
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