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Special Issue "Molecular Research of Selenocysteine in Selenoproteins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 92

Special Issue Editor

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
Interests: genetic code expansion; selenocysteine; system engineering; biophysics; synthetic biology

Special Issue Information

Dear Colleagues,

Selenium is an essential micronutrient for humans. Found primarily in the form of selenocysteine, the 21st naturally occurring amino acid, selenocysteine is incorporated into nascent selenoproteins at specified UGA codons through a sophisticated translation pathway developed by nature. These methods of biosynthesis and insertion of selenocysteine differ in all three domains of life. In humans, 25 identified selenoproteins have been linked to various diseases, including neurological, cardiovascular, reproductive, and infectious diseases, cancer, and diabetes. The pathologies of these diseases are associated with imbalances between the generation and elimination of reactive oxygen or nitrogen species. Selenoproteins are not unique to humans or eukaryotes, but play critical roles in bacterial physiology and archaeal methanogenesis. Various mouse and cell models and functional genomics, as well as advances in chemical, synthetic biology, and bioinformatics technologies, have significantly driven forward the field of selenium biology. This Special Issue welcomes submissions addressing any aspect of selenium and selenoproteins in any domain of life.

Dr. Natalie Krahn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • selenocysteine
  • selenoproteins
  • selenium
  • oxidoreductase
  • antioxidant
  • suppression

Published Papers

This special issue is now open for submission.
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