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Bioactive Compounds and Health 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 10 July 2024 | Viewed by 1806

Special Issue Editor


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Guest Editor
1. Inserm Research Center UMR1231 "Lipids, Nutrition, Cancer", Université de Bourgogne, 7 Blvd Jeanne d’Arc, 21000 Dijon, France
2. Centre de Lutte Contre le Cancer Georges-François Leclerc Center, 21000 Dijon, France
Interests: polyhenols; flavonoids; degenerative age-related diseases; inflammation; cancers; chemosensitization; lipid metabolism
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Special Issue Information

Dear Colleagues,

The last decade has been marked by an intense scientific interest in the use of bioactive compounds of various origins and their potential effects on human health, both from researchers and industry. These bioactive compounds have similar cellular targets to those of the new drugs developed by pharmaceutical companies. For example, the Food and Drug Administration (FDA) showed that 40% of the approved molecules are natural compounds or inspired by them, of which 74% are used in anticancer therapy. Pleiotropic pharmaceutical activities are used in fields such as cancer, inflammation, arthritis, cardiovascular diseases, auto-immune diseases, eye diseases, and many other domains. Among these bioactive compounds, polyphenols, fatty acids such as omega-3, oil extracts, and marine compounds could be candidates of choice to exert a preventive action against many of the evils of our century, and could act as therapeutic adjuvants.

This Special Issue follows the first edition, published in the International Journal of Molecular Sciences, which highlighted the current knowledge of various bioactive compounds and their derivatives, as well as the latest scientific advances in various domains, including metabolic diseases, cancers, degenerative age-related diseases, ocular diseases, and inflammatory/immune pathologies. I cordially invite authors to contribute their original articles as well as review articles that will provide readers of the International Journal of Molecular Sciences with updated and new perspectives on bioactive molecules and their derivatives, which could establish a new interest in the development of natural compounds for the following health subtopics: the structure–activity relationships of natural bioactive compounds; bioactive molecules and cancers; bioactive molecules and degenerative diseases; bioactive molecules and ocular diseases; bioactive molecules and inflammatory diseases; bioactive molecules and metabolic disorders; bioactive molecules and immune disorders.

Prof. Dr. Dominique Delmas
Guest Editor

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Keywords

  • polyphenols
  • polyunsaturated fatty acids
  • oil extracts
  • marine products
  • molecular mechanisms
  • signaling pathways
  • degenerative diseases
  • cancers
  • prevention
  • inflammation/immunity

Published Papers (1 paper)

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Research

25 pages, 4980 KiB  
Article
Metabolic Comparison and Molecular Networking of Antimicrobials in Streptomyces Species
by Bijaya Bahadur Thapa, Chen Huo, Rabin Budhathoki, Pratiksha Chaudhary, Soniya Joshi, Purna Bahadur Poudel, Rubin Thapa Magar, Niranjan Parajuli, Ki Hyun Kim and Jae Kyung Sohng
Int. J. Mol. Sci. 2024, 25(8), 4193; https://doi.org/10.3390/ijms25084193 - 10 Apr 2024
Viewed by 1487
Abstract
Streptomyces are well-known for producing bioactive secondary metabolites, with numerous antimicrobials essential to fight against infectious diseases. Globally, multidrug-resistant (MDR) microorganisms significantly challenge human and veterinary diseases. To tackle this issue, there is an urgent need for alternative antimicrobials. In the search for [...] Read more.
Streptomyces are well-known for producing bioactive secondary metabolites, with numerous antimicrobials essential to fight against infectious diseases. Globally, multidrug-resistant (MDR) microorganisms significantly challenge human and veterinary diseases. To tackle this issue, there is an urgent need for alternative antimicrobials. In the search for potent agents, we have isolated four Streptomyces species PC1, BT1, BT2, and BT3 from soils collected from various geographical regions of the Himalayan country Nepal, which were then identified based on morphology and 16S rRNA gene sequencing. The relationship of soil microbes with different Streptomyces species has been shown in phylogenetic trees. Antimicrobial potency of isolates was carried out against Staphylococcus aureus American Type Culture Collection (ATCC) 43300, Shigella sonnei ATCC 25931, Salmonella typhi ATCC 14028, Klebsiella pneumoniae ATCC 700603, and Escherichia coli ATCC 25922. Among them, Streptomyces species PC1 showed the highest zone of inhibition against tested pathogens. Furthermore, ethyl acetate extracts of shake flask fermentation of these Streptomyces strains were subjected to liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis for their metabolic comparison and Global Natural Products Social Molecular Networking (GNPS) web-based molecular networking. We found very similar metabolite composition in four strains, despite their geographical variation. In addition, we have identified thirty-seven metabolites using LC-MS/MS analysis, with the majority belonging to the diketopiperazine class. Among these, to the best of our knowledge, four metabolites, namely cyclo-(Ile-Ser), 2-n-hexyl-5-n-propylresorcinol, 3-[(6-methylpyrazin-2-yl) methyl]-1H-indole, and cyclo-(d-Leu-l-Trp), were detected for the first time in Streptomyces species. Besides these, other 23 metabolites including surfactin B, surfactin C, surfactin D, and valinomycin were identified with the help of GNPS-based molecular networking. Full article
(This article belongs to the Special Issue Bioactive Compounds and Health 2.0)
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