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Dietary Antioxidants for Health and Longevity
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Dietary Antioxidants for Health and Longevity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 6106

Special Issue Editors

Dr. Marika Cordaro

E-Mail Website
Guest Editor
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy
Interests: physiology; metabolites; inflammation; pathology; neurology
Special Issues, Collections and Topics in MDPI journals
Dr. Rossana Morabito

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy
Interests: oxidative stress events; glycation; aging; membrane transport systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diet-derived antioxidants are now being increasingly investigated for their health-promoting effects, including their role in the prevention of several pathologies, such as neurodegenerative, cardiovascular, and gastrointestinal diseases. An antioxidant nutrient, taking the above broad definition, is a compound present naturally in the diet, or added to it, which lowers the rate of production of deleterious changes by free radical reactions without significantly impairing the essential reactions involved in body maintenance and function. The beneficial effects of antioxidant nutrients are now supported by many studies, including those that have increased life span and lowered disease incidence. In general, antioxidant-rich food has received much attention, as it can be consumed for longer periods of time without any adverse effects.

This Special Issue on “Dietary Antioxidants for health and longevity” aims to cover all aspects of health promotion and prevention made by food with particular attention to all the molecular pathways involved.

Studies on phytochemical or nutraceutical effects that promote a healthy lifespan are welcome. Also, research articles collecting data from both in vivo and in vitro investigations are appreciated as well as full reviews, including news in the field on the current understanding of molecular mechanisms involved in the effects of food on human health.

Dr. Marika Cordaro
Prof. Dr. Rossana Morabito
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food
  • antioxidant
  • diet
  • molecular pathways
  • disease
  • nutraceutical
  • phytochemical

Published Papers (2 papers)

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Research

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19 pages, 2660 KiB  
Article
Antioxidant Activity of Quercetin in a H2O2-Induced Oxidative Stress Model in Red Blood Cells: Functional Role of Band 3 Protein
by Alessia Remigante, Sara Spinelli, Elisabetta Straface, Lucrezia Gambardella, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino and Rossana Morabito
Int. J. Mol. Sci. 2022, 23(19), 10991; https://doi.org/10.3390/ijms231910991 - 20 Sep 2022
Cited by 22 | Viewed by 2575
Abstract
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and are therefore considered as a suitable model to investigate cell response to oxidative stress (OS). This study was conducted to evaluate the potential beneficial effects of the [...] Read more.
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and are therefore considered as a suitable model to investigate cell response to oxidative stress (OS). This study was conducted to evaluate the potential beneficial effects of the natural antioxidant quercetin (Q) on an OS model represented by human RBCs treated with H2O2. Markers of OS, including % hemolysis, reactive oxygen species (ROS) production, thiobarbituric acid reactive substances (TBARS) levels, oxidation of protein sulfhydryl groups, CD47 and B3p expression, methemoglobin formation (% MetHb), as well as the anion exchange capability through Band 3 protein (B3p) have been analyzed in RBCs treated for 1 h with 20 mM H2O2 with or without pre-treatment for 1 h with 10 μM Q, or in RBCs pre-treated with 20 mM H2O2 and then exposed to 10 µM Q. The results show that pre-treatment with Q is more effective than post-treatment to counteract OS in RBCs. In particular, pre-exposure to Q avoided morphological alterations (formation of acanthocytes), prevented H2O2-induced OS damage, and restored the abnormal distribution of B3p and CD47 expression. Moreover, H2O2 exposure was associated with a decreased rate constant of SO42− uptake via B3p, as well as an increased MetHb formation. Both alterations have been attenuated by pre-treatment with 10 μM Q. These results contribute (1) to elucidate OS-related events in human RBCs, (2) propose Q as natural antioxidant to counteract OS-related alterations, and (3) identify B3p as a possible target for the treatment and prevention of OS-related disease conditions or aging-related complications impacting on RBCs physiology. Full article
(This article belongs to the Special Issue Dietary Antioxidants for Health and Longevity)
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Review

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25 pages, 3326 KiB  
Review
Bioactive Compounds of the Mediterranean Diet as Nutritional Support to Fight Neurodegenerative Disease
by Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola
Int. J. Mol. Sci. 2023, 24(8), 7318; https://doi.org/10.3390/ijms24087318 - 15 Apr 2023
Cited by 12 | Viewed by 2833
Abstract
Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress, and neuronal depletion. They include selective malfunction and progressive loss of neurons, glial cells, and neural networks in the brain and spinal cord. There is an urgent [...] Read more.
Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress, and neuronal depletion. They include selective malfunction and progressive loss of neurons, glial cells, and neural networks in the brain and spinal cord. There is an urgent need to develop new and more effective therapeutic strategies to combat these devastating diseases because, today, there is no treatment that can cure degenerative diseases; however, we have many symptomatic treatments. Current nutritional approaches are beginning to reflect a fundamental change in our understanding of health. The Mediterranean diet may have a protective effect on the neurodegenerative process because it is rich in antioxidants, fiber, and omega-3 polyunsaturated fatty acids. Increasing knowledge regarding the impact of diet on regulation at the genetic and molecular levels is changing the way we consider the role of nutrition, resulting in new dietary strategies. Natural products, thanks to their bioactive compounds, have recently undergone extensive exploration and study for their therapeutic potential for a variety of diseases. Targeting simultaneous multiple mechanisms of action and a neuroprotection approach with the diet could prevent cell death and restore function to damaged neurons. For these reasons, this review will be focused on the therapeutic potential of natural products and the associations between the Mediterranean-style diet (MD), neurodegenerative diseases, and markers and mechanisms of neurodegeneration. Full article
(This article belongs to the Special Issue Dietary Antioxidants for Health and Longevity)
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