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Special Issue "DNA/Polymer-Mediated Assembly of Nanoparticles"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 1364

Special Issue Editors

Department of Technology of Chemical Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia
Interests: nanoparticle preparation; polymers; biomaterials; nanobiotechnology; nanoscience; polymer nanoscience; nanotechnology in drug delivery; polymeric biomaterials; nanoparticles; controlled drug delivery
Laboratory of Histology-Embryology, School of Medicine, The University of Crete, 71003 Heraklion, Greece
Interests: matrix pathobiology; cancer; inflammation; oxidative stress; cytotoxicity
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Special Issue Information

Dear Colleagues,

Nanoparticle composites are versatile  and diverse functional materials, which find their application in different areas of science and technology ranging from catalysis and electronic devices fabrication to medicine and pharmaceutics. This special issue focuses on the use of chemical design to control the physico-chemical and structural attributes of polymer-mediated and DNA-mediated assembly of nanoparticles.

Polymer-nanoparticle composites are attracting great interest over the past few decades. As many traditional applications of composites require the nanoparticles to remain well dispersed within the polymer matrix, some of the novel proposed applications in medicine and pharmaceutics rely on higher-order organization of nanoparticles with the use of natural and synthetic polymers. Self-assembly provides a powerful and convenient approach for organizing nanoparticles in a highly effective tuneable design.

On the other hand, DNA nanotechnology, based on DNA sequence-specific recognition, can allow programmed self-assembly of nano-scaled structures with molecular precision. Extension of this technique to preparation of broader types of nanomaterials would significantly improve nanofabrication technique and even achieve single molecule operation. Using such DNA nanostructures as templates, chemical synthesis of inorganic and polymer nanomaterials could also be programmed with unprecedented flexibility and accuracy.

The aime of the special issue is to demonstrate the use of designed nanoparticles to create nanocomposites featuring interesting and pragmatic structures and properties. We will also describe applications of these engineered nanomaterials in different areas including biotechnology, pharmaceutics and medicine.

Dr. Andrey Kuskov
Prof. Dr. Dragana Nikitovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanoparticle
  • self-assembly
  • polymer-mediated
  • DNA-mediated
  • nanomedicine
  • material science
  • biomaterial
  • micelle
  • conjugate

Published Papers (1 paper)

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In Vitro Assessment of Poly-N-Vinylpyrrolidone/Acrylic Acid Nanoparticles Biocompatibility in a Microvascular Endothelium Model
Int. J. Mol. Sci. 2022, 23(20), 12446; https://doi.org/10.3390/ijms232012446 - 18 Oct 2022
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An amphiphilic copolymer of N-vinyl-2-pyrrolidone and acrylic acid—namely, p(VP-AA)-OD6000 (p(VP-AA))—was synthesized to prepare p(VP-AA) nanoparticles (NPs). Furthermore, the copolymer was linked with CFSE, and the so-prepared nanoparticles were loaded with the DiI dye to form D nanoparticles (DNPs). In this study, as demonstrated [...] Read more.
An amphiphilic copolymer of N-vinyl-2-pyrrolidone and acrylic acid—namely, p(VP-AA)-OD6000 (p(VP-AA))—was synthesized to prepare p(VP-AA) nanoparticles (NPs). Furthermore, the copolymer was linked with CFSE, and the so-prepared nanoparticles were loaded with the DiI dye to form D nanoparticles (DNPs). In this study, as demonstrated by immunofluorescence microscopy, immunofluorescence, and confocal microscopy, DNPs were readily taken up by human microvascular endothelial cells (HMEC-1) cells in a concentration-dependent manner. Upon uptake, both the CFSE dye (green stain) and the DiI dye (red stain) were localized to the cytoplasm of treated cells. Treatment with p(VP-AA) did not affect the viability of normal and challenged with LPS, HMEC-1 cells at 0.010 mg/mL and induced a dose-dependent decrease of these cells’ viability at the higher concentrations of 0.033 and 0.066 mg/mL (p ≤ 0.01; p ≤ 0.001, respectively). Furthermore, we focused on the potential immunological activation of HMEC-1 endothelial cells upon p(VP-AA) NPs treatment by assessing the expression of adhesion molecules (E-Selectin, ICAM-1, and V-CAM). NPs treatments at concentrations utilized (p = NS) did not affect individual adhesion molecules’ expression. p(VP-AA) NPs do not activate the endothelium and do not affect its viability at pharmacologically relevant concentrations. Full article
(This article belongs to the Special Issue DNA/Polymer-Mediated Assembly of Nanoparticles)
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