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The Effect of Dietary Antioxidants on Metabolic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 5355

Special Issue Editors

CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
Interests: natural compounds; nutraceuticals; natural products; food science and nutrition; food composition databases; bioaccesibility; dietary intake
Special Issues, Collections and Topics in MDPI journals
CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
Interests: bioactive compounds; natural products; nutraceuticals; antioxidants; dietary supplements; food quality; nutrition; food composition databases; bioavailability, metabolic pathway; nanoformulations
Special Issues, Collections and Topics in MDPI journals
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria – Centro di ricerca Alimenti e Nutrizione, Via Ardeatina 546, 00178 Rome, Italy
Interests: natural compounds; nutraceuticals; natural products; food science and nutrition; food composition databases; bioaccessibility; dietary intake; healthy diet
Special Issues, Collections and Topics in MDPI journals
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
Interests: food chemistry; safety; food safety; nutraceuticals; nanonutraceuticals; recovery from byproducts of the food industry; food contaminants; food supplements; contaminants; risk assessment; mycotoxins and secondary metabolites; chemistry and food education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues

With the change in people's diets and lifestyles, the number of patients with metabolic diseases such as diabetes, obesity and gout is on the rise. The rational use of dietary supplements has the potential to prevent diseases and promote health. Some studies have shown that dietary antioxidant nutrients (such as ascorbic acid, β-carotene, vitamin E and selenium) can have preventive and therapeutic effects on some metabolic diseases. However, the true impact of these dietary antioxidants and their mechanisms of action have yet to be completely elucidated.

This Special Issue is therefore focused on recent advances in the study of the health benefits of dietary antioxidants against metabolic diseases, as well as on the discovery of novel molecular therapeutic mechanisms, and the testing of novel targeted therapies. The exact active ingredient contained within an extract of natural origin must be reported in the submitted research manuscript, since papers describing the effects of mixed extractions of natural origin are not within the scope of the journal.

Prof. Dr. Massimo Lucarini
Dr. Alessandra Durazzo
Dr. Ginevra Lombardi-Boccia
Prof. Dr. Antonello Santini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary antioxidants
  • vitamin
  • phenols
  • diabetes
  • metabolic diseases
  • molecular mechanisms

Published Papers (3 papers)

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Editorial

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3 pages, 662 KiB  
Editorial
Dietary Antioxidants and Metabolic Diseases
Int. J. Mol. Sci. 2021, 22(22), 12558; https://doi.org/10.3390/ijms222212558 - 22 Nov 2021
Cited by 4 | Viewed by 1533
Abstract
Introduction [...] Full article
(This article belongs to the Special Issue The Effect of Dietary Antioxidants on Metabolic Diseases)
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Research

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21 pages, 6225 KiB  
Article
The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue
Int. J. Mol. Sci. 2023, 24(11), 9490; https://doi.org/10.3390/ijms24119490 - 30 May 2023
Viewed by 1459
Abstract
Diabetes mellitus is a public health concern, affecting 10.5% of the population. Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes. This study investigated the role of PCA in improving insulin resistance and the crosstalk between muscle with liver [...] Read more.
Diabetes mellitus is a public health concern, affecting 10.5% of the population. Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes. This study investigated the role of PCA in improving insulin resistance and the crosstalk between muscle with liver and adipose tissue. C2C12 myotubes received four treatments: Control, PCA, insulin resistance (IR), and IR-PCA. Conditioned media from C2C12 was used to incubate HepG2 and 3T3-L1 adipocytes. The impact of PCA was analyzed on glucose uptake and signaling pathways. PCA (80 µM) significantly enhanced glucose uptake in C2C12, HepG2, and 3T3-L1 adipocytes (p < 0.05). In C2C12, PCA significantly elevated GLUT-4, IRS-1, IRS-2, PPAR-γ, P-AMPK, and P-Akt vs. Control (p ≤ 0.05), and modulated pathways in IR-PCA. In HepG2, PPAR-γ and P-Akt increased significantly in Control (CM) vs. No CM, and PCA dose upregulated PPAR-γ, P-AMPK, and P-AKT (p < 0.05). In the 3T3-L1 adipocytes, PI3K and GLUT-4 expression was elevated in PCA (CM) vs. No CM. A significant elevation of IRS-1, GLUT-4, and P-AMPK was observed in IR-PCA vs. IR (p ≤ 0.001). Herein, PCA strengthens insulin signaling by activating key proteins of that pathway and regulating glucose uptake. Further, conditioned media modulated crosstalk between muscle with liver and adipose tissue, thus regulating glucose metabolism. Full article
(This article belongs to the Special Issue The Effect of Dietary Antioxidants on Metabolic Diseases)
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12 pages, 3462 KiB  
Article
Protective Effects of Epigallocatechin Gallate for Male Sexual Dysfunction in Streptozotocin-Induced Diabetic Rats
Int. J. Mol. Sci. 2022, 23(17), 9759; https://doi.org/10.3390/ijms23179759 - 28 Aug 2022
Cited by 1 | Viewed by 1454
Abstract
Sexual dysfunction is a common problem for men with diabetes. Epigallocatechin gallate (EGCG) is known to ameliorate erectile function in aging rats. However, there has not yet been a report to evaluate its effects on diabetic male rat sexual behavior in the literature. [...] Read more.
Sexual dysfunction is a common problem for men with diabetes. Epigallocatechin gallate (EGCG) is known to ameliorate erectile function in aging rats. However, there has not yet been a report to evaluate its effects on diabetic male rat sexual behavior in the literature. In this study, we investigated the effects of EGCG on male sexual behavior in diabetic rats. Diabetic rats were induced by a single intraperitoneal injection of 65 mg/kg of streptozotocin. After streptozotocin injection for one week, animals were then orally treated with 40 mg/kg of EGCG or vehicle. Copulatory behavior and fasting blood glucose levels were recorded before treatment, as well as 7 and 14 days after treatment. Serum LH, testosterone, and PDE5a levels were measured by EIA assay after the last behavioral test. Data showed that diabetic rats who had diminished sexual functions demonstrated significantly increased latencies in mount, intromission, and ejaculation, as well as significant decreases in frequencies of intromission and ejaculation, compared to non-diabetic controls, indicating sexual function recovery. Lower blood glucose levels were also found in diabetic rats after EGCG treatment. Additionally, the lower LH and higher PDE5a levels in diabetic rats than controls were also noted. The findings declared that EGCG had a protective effect on male sexual behavior in diabetic rats. Full article
(This article belongs to the Special Issue The Effect of Dietary Antioxidants on Metabolic Diseases)
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