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Modulation of Ion Channels
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Modulation of Ion Channels

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 10 July 2024 | Viewed by 4822

Special Issue Editor

Dr. Jian Shi

E-Mail Website
Guest Editor
Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
Interests: ion channel physiology; ion channel pharmacology; ion channel biophysics; electrophysiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ion channels play a pivotal role in dictating physiological functions of cells or tissues. The passage of ions such as calcium, potassium, sodium and chloride etc across the impermeable lipid cell membrane controls many cellular processes including cell swelling, cell contraction, nutrient transport, hormone or insulin release, pain signal transmission and so on. Disruption of normal ion channel functions resulting from either a mutation in the gene encoding ion channel or its regulatory proteins or change of membrane lipid environment could cause a multitude of diseases (e.g. hypertension, diabetes, diarrhea, long QT syndrome, epilepsy and cystic fibrosis). Therefore, It is important to understand the fundamental questions on ion channels and develop new tools and techniques for ion channels.

In this special issue, we are dedicated to publishing high-quality papers (either research papers or review papers) covering a wide of range of ion channel topics. In addtion to reporting innovative techniques for ion channel research and new pharmacological knowledge of ion channels, we will highlight novel regulations of ion channels and their roles at all levels. The papers studying structure-function relationship, biophysical characterisation, physiological or pathophysiological roles, pharmacology and new tools of ion channels are all welcomed for this special issue. 

Dr. Jian Shi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ion channel structure
  • ion channel functions
  • ion channel pharmacology
  • ion channel and diseases
  • innovative techniques for ion channel research

Published Papers (3 papers)

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Research

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16 pages, 4283 KiB  
Article
Loose Coupling between the Voltage Sensor and the Activation Gate in Mammalian HCN Channels Suggests a Gating Mechanism
by Xiaoan Wu, Kevin P. Cunningham, Andrew Bruening-Wright, Shilpi Pandey and H. Peter Larsson
Int. J. Mol. Sci. 2024, 25(8), 4309; https://doi.org/10.3390/ijms25084309 - 13 Apr 2024
Viewed by 335
Abstract
Voltage-gated potassium (Kv) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels share similar structures but have opposite gating polarity. Kv channels have a strong coupling (>109) between the voltage sensor (S4) and the activation gate: when S4s are activated, the gate is [...] Read more.
Voltage-gated potassium (Kv) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels share similar structures but have opposite gating polarity. Kv channels have a strong coupling (>109) between the voltage sensor (S4) and the activation gate: when S4s are activated, the gate is open to >80% but, when S4s are deactivated, the gate is open <10−9 of the time. Using noise analysis, we show that the coupling between S4 and the gate is <200 in HCN channels. In addition, using voltage clamp fluorometry, locking the gate open in a Kv channel drastically altered the energetics of S4 movement. In contrast, locking the gate open or decreasing the coupling between S4 and the gate in HCN channels had only minor effects on the energetics of S4 movement, consistent with a weak coupling between S4 and the gate. We propose that this loose coupling is a prerequisite for the reversed voltage gating in HCN channels. Full article
(This article belongs to the Special Issue Modulation of Ion Channels)
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Review

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32 pages, 676 KiB  
Review
Flavonoids as Modulators of Potassium Channels
by Monika Richter-Laskowska, Paulina Trybek, Domenico Vittorio Delfino and Agata Wawrzkiewicz-Jałowiecka
Int. J. Mol. Sci. 2023, 24(2), 1311; https://doi.org/10.3390/ijms24021311 - 09 Jan 2023
Cited by 7 | Viewed by 2992
Abstract
Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important molecular [...] Read more.
Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important molecular drug targets due to their physiological roles, including the regulation of membrane potential or cell signaling. One of the recent trends in molecular pharmacology is the evaluation of the therapeutic potential of natural compounds and their derivatives, which can exhibit high specificity and effectiveness. Among the pharmaceuticals of plant origin, which are potassium channel modulators, flavonoids appear as a powerful group of biologically active substances. It is caused by their well-documented anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, and antidiabetic effects on human health. Here, we focus on presenting the current state of knowledge about the possibilities of modulation of particular types of potassium channels by different flavonoids. Additionally, the biological meaning of the flavonoid-mediated changes in the activity of K+ channels will be outlined. Finally, novel promising directions for further research in this area will be proposed. Full article
(This article belongs to the Special Issue Modulation of Ion Channels)
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Other

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7 pages, 798 KiB  
Brief Report
Piezo1 Activation Prevents Spheroid Formation by Malignant Melanoma SK-MEL-2 Cells
by Valeria Y. Vasileva, Zuleikha M. Khairullina and Vladislav I. Chubinskiy-Nadezhdin
Int. J. Mol. Sci. 2023, 24(21), 15703; https://doi.org/10.3390/ijms242115703 - 28 Oct 2023
Cited by 1 | Viewed by 833
Abstract
Melanoma is a highly aggressive type of skin cancer produced through the malignant transformation of melanocytes, and it is usually associated with a poor prognosis. Clinically, melanoma has several stages associated with migration and invasion of the cells through the skin’s layers, the [...] Read more.
Melanoma is a highly aggressive type of skin cancer produced through the malignant transformation of melanocytes, and it is usually associated with a poor prognosis. Clinically, melanoma has several stages associated with migration and invasion of the cells through the skin’s layers, the rapid spreading of cells and the formation of tumors in multiple organs. The main problem is the emergence of resistance in melanoma to the applied methods of treatment; thus, it is of primary importance to find more crucial signaling pathways that control the progression of this type of cancer and could be targeted to prevent melanoma spreading. Here, we uncover novel aspects of the role of the mechanosensitive ion channel Piezo1 in melanoma tumor formation. Using a combinative approach, we showed the functional expression of mechanosensitive Piezo1 channels in the aggressive human melanoma SK-MEL-2 cell line. We found that chemical activation of Piezo1 by its agonist, Yoda1, prevents melanoma spheroid formation; thus, Piezo1 could be a potential target for selective modulation aimed at the prevention of melanoma development. Full article
(This article belongs to the Special Issue Modulation of Ion Channels)
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