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Special Issue "Modulation of Ion Channels"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 2016

Special Issue Editor

Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
Interests: ion channel physiology; ion channel pharmacology; ion channel biophysics; electrophysiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ion channels play a pivotal role in dictating physiological functions of cells or tissues. The passage of ions such as calcium, potassium, sodium and chloride etc across the impermeable lipid cell membrane controls many cellular processes including cell swelling, cell contraction, nutrient transport, hormone or insulin release, pain signal transmission and so on. Disruption of normal ion channel functions resulting from either a mutation in the gene encoding ion channel or its regulatory proteins or change of membrane lipid environment could cause a multitude of diseases (e.g. hypertension, diabetes, diarrhea, long QT syndrome, epilepsy and cystic fibrosis). Therefore, It is important to understand the fundamental questions on ion channels and develop new tools and techniques for ion channels.

In this special issue, we are dedicated to publishing high-quality papers (either research papers or review papers) covering a wide of range of ion channel topics. In addtion to reporting innovative techniques for ion channel research and new pharmacological knowledge of ion channels, we will highlight novel regulations of ion channels and their roles at all levels. The papers studying structure-function relationship, biophysical characterisation, physiological or pathophysiological roles, pharmacology and new tools of ion channels are all welcomed for this special issue. 

Dr. Jian Shi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ion channel structure
  • ion channel functions
  • ion channel pharmacology
  • ion channel and diseases
  • innovative techniques for ion channel research

Published Papers (1 paper)

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Review

Review
Flavonoids as Modulators of Potassium Channels
Int. J. Mol. Sci. 2023, 24(2), 1311; https://doi.org/10.3390/ijms24021311 - 09 Jan 2023
Cited by 2 | Viewed by 1763
Abstract
Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important molecular [...] Read more.
Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important molecular drug targets due to their physiological roles, including the regulation of membrane potential or cell signaling. One of the recent trends in molecular pharmacology is the evaluation of the therapeutic potential of natural compounds and their derivatives, which can exhibit high specificity and effectiveness. Among the pharmaceuticals of plant origin, which are potassium channel modulators, flavonoids appear as a powerful group of biologically active substances. It is caused by their well-documented anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, and antidiabetic effects on human health. Here, we focus on presenting the current state of knowledge about the possibilities of modulation of particular types of potassium channels by different flavonoids. Additionally, the biological meaning of the flavonoid-mediated changes in the activity of K+ channels will be outlined. Finally, novel promising directions for further research in this area will be proposed. Full article
(This article belongs to the Special Issue Modulation of Ion Channels)
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