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Special Issue "Cellular and Molecular Mechanisms of Heart Development and Regeneration"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 January 2024 | Viewed by 274

Special Issue Editor

IGF, CNRS, INSERM, Université de Montpellier, Labex ICST, F-34094 Montpellier, France
Interests: molecular mechanisms; cardiac development; cardiac disease; cardiac regeneration; heart regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human heart is one of the first organs to develop and continuously pumps blood around the body for decades of life, long after it is evolutionarily required. Heart development is an intricate process that commences when clusters of cells form the primitive heart tube, which subseqeuntly undergoes dynamic changes in morphology and cellular composition before finally establishing a fully functional and mature heart. The cellular and molecular processes that drive cardiac development are finely balanced, and any disruption can lead to a variety of cardiac diseases. Recent advances in genome editing using CRISPR/Cas9, coupled with the rise of next-generation sequencing and single-cell transcriptomics, are allowing us to rapidly gain insights into the molecular and cellular processes that drive cardiac development, which may be associated not only with cardiac disease, but also the exciting prospect of cardiac regeneration. With the aid of animal models, it is becoming apparent that the molecular and cellular processes occurring during cardiac development also play fundamental roles during cardiac regeneration. Perhaps the most well-known example is when mature cardiomyocytes dedifferentiate back to an earlier developmental stage, which allows them proliferate and ultimately regenerate the damaged heart. Therefore, understanding more about the cellular and molecular processes that drive heart development will not only increase our understanding of cardiac disease, but also increase the possibility of identifying factors that trigger cardiac regeneration.

This Special Issue aims to highlight recent advances in our understanding of the cellular and molecular mechanisms of cardiac development and their implications in heart disease and regeneration. The topics may include (but are not limited to) the following:

  • Myocardium/endocardium/epicardium;
  • Neural crest cells;
  • Second heart field;
  • Cardiac fibroblasts;
  • Cardiac valves;
  • Cardiomyopathies;
  • Congenital heart defects;
  • Arrhythmias;
  • Inflammation;
  • iPS-derived models;
  • Animal models;
  • Transcriptomics, e.g., single cell/nuclei.

Dr. Chris Jopling
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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