Special Issue "Cellular and Molecular Mechanisms of Heart Development and Regeneration"
Deadline for manuscript submissions: 30 January 2024 | Viewed by 274
Interests: molecular mechanisms; cardiac development; cardiac disease; cardiac regeneration; heart regeneration
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The human heart is one of the first organs to develop and continuously pumps blood around the body for decades of life, long after it is evolutionarily required. Heart development is an intricate process that commences when clusters of cells form the primitive heart tube, which subseqeuntly undergoes dynamic changes in morphology and cellular composition before finally establishing a fully functional and mature heart. The cellular and molecular processes that drive cardiac development are finely balanced, and any disruption can lead to a variety of cardiac diseases. Recent advances in genome editing using CRISPR/Cas9, coupled with the rise of next-generation sequencing and single-cell transcriptomics, are allowing us to rapidly gain insights into the molecular and cellular processes that drive cardiac development, which may be associated not only with cardiac disease, but also the exciting prospect of cardiac regeneration. With the aid of animal models, it is becoming apparent that the molecular and cellular processes occurring during cardiac development also play fundamental roles during cardiac regeneration. Perhaps the most well-known example is when mature cardiomyocytes dedifferentiate back to an earlier developmental stage, which allows them proliferate and ultimately regenerate the damaged heart. Therefore, understanding more about the cellular and molecular processes that drive heart development will not only increase our understanding of cardiac disease, but also increase the possibility of identifying factors that trigger cardiac regeneration.
This Special Issue aims to highlight recent advances in our understanding of the cellular and molecular mechanisms of cardiac development and their implications in heart disease and regeneration. The topics may include (but are not limited to) the following:
- Neural crest cells;
- Second heart field;
- Cardiac fibroblasts;
- Cardiac valves;
- Congenital heart defects;
- iPS-derived models;
- Animal models;
- Transcriptomics, e.g., single cell/nuclei.
Dr. Chris Jopling
Manuscript Submission Information
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